STATs are latent transcription factors that mediate cytokine- and growth factor–directed
transcription. In many human cancers and transformed cell lines, Stat3 is persistently activated, …

β-Catenin plays a dual role in the cell: one in linking the cytoplasmic side of cadherin-mediated
cell–cell contacts to the actin cytoskeleton and an additional role in signaling that …

Accumulating evidence implicates the transcription factor NF-κB as a positive mediator of cell
growth, but the molecular mechanism (s) involved in this process remains largely unknown…

Several different oncogenes and growth factors promote G 1 phase progression. Cyclin D1,
the regulatory subunit of several cyclin-dependent kinases, is required for, and capable of …

We demonstrate that a Rho kinase inhibitor (Y-27632), in combination with fibroblast feeder
cells, induces normal and tumor epithelial cells from many tissues to proliferate indefinitely …

Induction of cyclin D1 gene transcription by estrogen receptor α (ERα) plays an important role
in estrogen-mediated proliferation. There is no classical estrogen response element in the …

The cyclins are a family of proteins that are centrally involved in cell cycle regulation and which
are structurally identified by conserved “cyclin box” regions. They are regulatory subunits …

The major pathological features of Alzheimer’s disease (AD) include amyloid plaques
composed primarily of the β-amyloid (Aβ) peptide, degenerating neurons and neurofibrillary …

Regulation of nuclear receptor gene expression involves dynamic and coordinated interactions
with histone acetyl transferase (HAT) and deacetylase complexes. The estrogen receptor …

A. Single-transmembrane segment receptors B. Seven-transmembrane receptors C. Steroid
hormones D. Intracellular second messengers IV. Cyclins and CKIs in Endocrine Tumors A. …