Structural variations of DNA greater than 1 kilobase in size account for most bases that vary
among human genomes, but are still relatively under-ascertained. Here we use tiling …

Most cancer genomic data are generated from bulk samples composed of mixtures of
cancer subpopulations, as well as normal cells. Subclonal reconstruction methods based on …

This study aimed to investigate position-specific evolution of physical and technical performance
parameters in the English Premier League (EPL). Match performance observations (n = …

Developmental haemostasis is a concept, now universally accepted, introduced by Andrew
et al. in the late 1980’s. However, coagulation analysers and reagents have changed …

We report the first genome-wide association study (GWAS) whose sample size (1,053 Swedish
subjects) is sufficiently powered to detect genome-wide significance (p<1.5×10 −7 ) for …

The aim of this study was to compare the match performance and physical capacity of players
in the top three competitive standards of English soccer. Match performance data were …

Despite extraordinary efforts to profile cancer genomes, interpreting the vast amount of
genomic data in the light of cancer evolution remains challenging. Here we demonstrate that …

Subclonal architectures are prevalent across cancer types. However, the temporal evolutionary
dynamics that produce tumor subclones remain unknown. Here we measure clone …

This study examined the evolution of physical and technical soccer performance across a 7-season
period in the English Premier League. Match performance observations (n=14 700) …

Copy number variation (CNV) is pervasive in the human genome and can play a causal role
in genetic diseases. The functional impact of CNV cannot be fully captured through linkage …