Skeletal muscle carnitine loading increases energy expenditure, modulates fuel metabolism gene networks and prevents body fat accumulation in humans
…, BT Wall, K Marimuthu, CE Shannon… - The Journal of …, 2013 - Wiley Online Library
Key points • Carnitine is a substrate for the carnitine palmitoyltransferase 1 enzyme, a rate‐limiting
step in fatty acid oxidation within skeletal muscle. • Insulin stimulates carnitine …
step in fatty acid oxidation within skeletal muscle. • Insulin stimulates carnitine …
Lipid-induced insulin resistance is associated with an impaired skeletal muscle protein synthetic response to amino acid ingestion in healthy young men
…, C Chee, BT Wall, AJ Murton, CE Shannon… - Diabetes, 2015 - Am Diabetes Assoc
The ability to maintain skeletal muscle mass appears to be impaired in insulin-resistant
conditions, such as type 2 diabetes, that are characterized by muscle lipid accumulation. The …
conditions, such as type 2 diabetes, that are characterized by muscle lipid accumulation. The …
Relative contribution of intramyocellular lipid to whole-body fat oxidation is reduced with age but subsarcolemmal lipid accumulation and insulin resistance are only …
C Chee, CE Shannon, A Burns, AL Selby… - Diabetes, 2016 - Am Diabetes Assoc
Insulin resistance is closely related to intramyocellular lipid (IMCL) accumulation, and both
are associated with increasing age. It remains to be determined to what extent perturbations …
are associated with increasing age. It remains to be determined to what extent perturbations …
[HTML][HTML] Insulin resistance is mechanistically linked to hepatic mitochondrial remodeling in non-alcoholic fatty liver disease
… Author links open overlay panel Chris E. Shannon 1 , Mukundan Ragavan 2 , Juan Pablo
Palavicini 1 3 , Marcel Fourcaudot 1 , Terry M Bakewell 1 , Ivan A. Valdez 1 , Iriscilla Ayala 1 , …
Palavicini 1 3 , Marcel Fourcaudot 1 , Terry M Bakewell 1 , Ivan A. Valdez 1 , Iriscilla Ayala 1 , …
Increasing skeletal muscle carnitine content in older individuals increases whole‐body fat oxidation during moderate‐intensity exercise
C Chee, CE Shannon, A Burns, AL Selby… - Aging …, 2021 - Wiley Online Library
Intramyocellular lipid (IMCL) utilization is impaired in older individuals, and IMCL accumulation
is associated with insulin resistance. We hypothesized that increasing muscle total …
is associated with insulin resistance. We hypothesized that increasing muscle total …
Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation
FB Stephens, B Mendis, CE Shannon… - Clinical …, 2014 - portlandpress.com
Acylcarnitine accumulation in skeletal muscle and plasma has been observed in numerous
models of mitochondrial lipid overload and insulin resistance. Fish oil n3PUFA (omega-3 …
models of mitochondrial lipid overload and insulin resistance. Fish oil n3PUFA (omega-3 …
[HTML][HTML] The insulin-sensitizer pioglitazone remodels adipose tissue phospholipids in humans
…, M Pan, L Norton, RA DeFronzo, CE Shannon - Frontiers in …, 2021 - frontiersin.org
The insulin-sensitizer pioglitazone exerts its cardiometabolic benefits in type 2 diabetes (T2D)
through a redistribution of body fat, from ectopic and visceral areas to subcutaneous …
through a redistribution of body fat, from ectopic and visceral areas to subcutaneous …
[HTML][HTML] Precision nutrition for targeting pathophysiology of cardiometabolic phenotypes
CE Shannon, MB Ní Chathail, SM Mullin… - Reviews in Endocrine …, 2023 - Springer
Obesity is a heterogenous disease accompanied by a broad spectrum of cardiometabolic
risk profiles. Traditional paradigms for dietary weight management do not address biological …
risk profiles. Traditional paradigms for dietary weight management do not address biological …
Regulation of ANGPTL8 in liver and adipose tissue by nutritional and hormonal signals and its effect on glucose homeostasis in mice
L Zhang, CE Shannon, TM Bakewell… - American Journal …, 2020 - journals.physiology.org
The angiopoietin-like protein (ANGPTL) family represents a promising therapeutic target for
dyslipidemia, which is a feature of obesity and type 2 diabetes (T2DM). The aim of the …
dyslipidemia, which is a feature of obesity and type 2 diabetes (T2DM). The aim of the …
Pioglitazone inhibits mitochondrial pyruvate metabolism and glucose production in hepatocytes
CE Shannon, G Daniele, C Galindo… - The FEBS …, 2017 - Wiley Online Library
Pioglitazone is used globally for the treatment of type 2 diabetes mellitus (T2DM) and is one
of the most effective therapies for improving glucose homeostasis and insulin resistance in …
of the most effective therapies for improving glucose homeostasis and insulin resistance in …