Target identification (determining the correct drug targets for a disease) and target validation
(demonstrating an effect of target perturbation on disease biomarkers and disease end …

Objectives Researchers often perform arbitrary outcome transformations to fulfill the normality
assumption of a linear regression model. This commentary explains and illustrates that in …

Aims To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and
triglycerides in coronary heart disease (CHD) using multiple instrumental variables for Mendelian …

Objective To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as
an instrument to investigate the causal role of alcohol in cardiovascular disease. Design …

Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion
of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide …

Spontaneous coronary artery dissection (SCAD) is an understudied cause of myocardial
infarction primarily affecting women. It is not known to what extent SCAD is genetically distinct …

Mendelian randomisation (MR) analysis is an important tool to elucidate the causal relevance
of environmental and biological risk factors for disease. However, causal inference is …

Drugs whose targets have genetic evidence to support efficacy and safety are more likely to
be approved after clinical development. In this paper, we provide an overview of how natural …

Background Globally, there is a paucity of multimorbidity and comorbidity data, especially
for minority ethnic groups and younger people. We estimated the frequency of common …

Genomic studies in African populations provide unique opportunities to understand disease
etiology, human diversity, and population history. In the largest study of its kind, comprising …