Hematopoietic stem cells (HSCs) and an earlier wave of definitive erythroid/myeloid progenitors
(EMPs) differentiate from hemogenic endothelial cells in the conceptus. EMPs can be …

Knowledge of the key transcription factors that drive hematopoietic stem cell (HSC)
generation is of particular importance for current hematopoietic regenerative approaches and …

Hematopoietic stem cells (HSCs) are generated via a natural transdifferentiation process
known as endothelial to hematopoietic cell transition (EHT). Because of small numbers of …

… In the original version of this Article, the middle initial of the author Chris S. Vink was
omitted from the author information. This has now been corrected in both the PDF and HTML …

Hematopoietic stem cells (HSCs) are generated from specialized endothelial cells of the
embryonic aorta. Inflammatory factors are implicated in regulating mouse HSC development, …

The central nervous system hosts parenchymal macrophages, known as microglia, and non-parenchymal
macrophages, collectively termed border-associated macrophages (BAMs). …

Whereas hundreds of cells in the mouse embryonic aorta transdifferentiate to hematopoietic
cells, only very few establish hematopoietic stem cell (HSC) identity at a single time point. …

Hypoxia affects many physiologic processes during early stages of mammalian ontogeny,
particularly placental and vascular development. In the adult, the hypoxic bone marrow …

Hematopoietic stem cells (HSCs) develop from the hemogenic endothelium in cluster
structures that protrude into the embryonic aortic lumen. Although much is known about the …

10.7554/eLife.43271.001 The origins and functions of kidney macrophages in the adult
have been explored, but their roles during development remain largely unknown. Here we …