User profiles for Christa Caggiano
 | Christa CaggianoPostdoctoral fellow, Institute of Genomic Health, Mt Sinai School of Medicine Verified email at mssm.edu Cited by 110 |
[HTML][HTML] Comprehensive cell type decomposition of circulating cell-free DNA with CelFiE
Circulating cell-free DNA (cfDNA) in the bloodstream originates from dying cells and is a
promising noninvasive biomarker for cell death. Here, we propose an algorithm, CelFiE, to …
promising noninvasive biomarker for cell death. Here, we propose an algorithm, CelFiE, to …
[HTML][HTML] Leveraging genomic diversity for discovery in an electronic health record linked biobank: the UCLA ATLAS Community Health Initiative
Background Large medical centers in urban areas, like Los Angeles, care for a diverse
patient population and offer the potential to study the interplay between genetic ancestry and …
patient population and offer the potential to study the interplay between genetic ancestry and …
Genome-wide study of the effect of blood collection tubes on the cell-free DNA methylome
The methylation pattern of cfDNA, isolated from liquid biopsies, is gaining substantial interest
for diagnosis and monitoring of diseases. We have evaluated the impact of type of blood …
for diagnosis and monitoring of diseases. We have evaluated the impact of type of blood …
Disease risk and healthcare utilization among ancestrally diverse groups in the Los Angeles region
An individual’s disease risk is affected by the populations that they belong to, due to shared
genetics and environmental factors. The study of fine-scale populations in clinical care is …
genetics and environmental factors. The study of fine-scale populations in clinical care is …
Leveraging genomic diversity for discovery in an EHR-linked biobank: the UCLA ATLAS Community Health Initiative
Large medical centers located in urban areas such as Los Angeles care for a diverse patient
population and offer the potential to study the interplay between genomic ancestry and …
population and offer the potential to study the interplay between genomic ancestry and …
[PDF][PDF] Cell-type deconvolution of bulk-blood RNA-seq reveals biological insights into neuropsychiatric disorders
Genome-wide association studies (GWASs) have uncovered susceptibility loci associated
with psychiatric disorders such as bipolar disorder (BP) and schizophrenia (SCZ). However, …
with psychiatric disorders such as bipolar disorder (BP) and schizophrenia (SCZ). However, …
Robust sequence determinants of α-synuclein toxicity in yeast implicate membrane binding
…, TS Wu, D Barrero, C Caggiano… - ACS chemical …, 2020 - ACS Publications
Protein conformations are shaped by cellular environments, but how environmental
changes alter the conformational landscapes of specific proteins in vivo remains largely …
changes alter the conformational landscapes of specific proteins in vivo remains largely …
Health care utilization of fine-scale identity by descent clusters in a Los Angeles biobank
1 Abstract An individual’s disease risk is affected by the populations that they belong to, due
to shared genetics and shared environment. The study of fine-scale populations in clinical …
to shared genetics and shared environment. The study of fine-scale populations in clinical …
Estimating the rate of cell type degeneration from epigenetic sequencing of cell-free DNA
Cells die at different rates as a function of disease state, age, environmental exposure, and
behavior [ 8 , 10 ]. Knowing the rate at which cells die is a fundamental scientific question, …
behavior [ 8 , 10 ]. Knowing the rate at which cells die is a fundamental scientific question, …
Tissue informative cell-free DNA methylation sites in amyotrophic lateral sclerosis
Cell-free DNA (cfDNA) is increasingly recognized as a promising biomarker candidate for
disease monitoring. However, its utility in neurodegenerative diseases, like amyotrophic lateral …
disease monitoring. However, its utility in neurodegenerative diseases, like amyotrophic lateral …