Antibody optimization enabled by artificial intelligence predictions of binding affinity and naturalness

…, JM Gutierrez, E Yassine, B Medjo, V Blay, C Kohnert… - BioRxiv, 2022 - biorxiv.org
Traditional antibody optimization approaches involve screening a small subset of the
available sequence space, often resulting in drug candidates with suboptimal binding affinity, …

Unlocking de novo antibody design with generative artificial intelligence

…, G Kasun, JM Sutton, AK Steiger, R Shuai, C Kohnert… - bioRxiv, 2023 - biorxiv.org
Generative artificial intelligence (AI) has the potential to greatly increase the speed, quality
and controllability of antibody design. Traditional de novo antibody discovery requires time …

Large‐scale molecular diet analysis in a generalist marine mammal reveals male preference for prey of conservation concern

…, SM Spitzer, AC Thomas, CM Kohnert… - Ecology and …, 2018 - Wiley Online Library
Sex‐specific diet information is important in the determination of predator impacts on prey
populations. Unfortunately, the diet of males and females can be difficult to describe, …

Deep learning-based codon optimization with large-scale synonymous variant datasets enables generalized tunable protein expression

…, H Carter, AB Ventura, MTM Louie, C Kohnert… - bioRxiv, 2023 - biorxiv.org
Increasing recombinant protein expression is of broad interest in industrial biotechnology,
synthetic biology, and basic research. Codon optimization is an important step in heterologous …

In vitro validated antibody design against multiple therapeutic antigens using generative inverse folding

…, D Chapman, R Consbruck, A Jaeger, C Kohnert… - bioRxiv, 2023 - biorxiv.org
Deep learning approaches have demonstrated the ability to design protein sequences given
backbone structures [1, 2, 3, 4, 5]. While these approaches have been applied in silico to …

Physiological Mechanisms of Desiccation Resistance in Fruit-Parasitic Rhagoletis Flies

CM Kohnert - 2017 - cedar.wwu.edu
Understanding drought adaptation in fruit-parasitic Rhagoletis flies is essential for evaluating
the potential for eastward spread of the invasive apple maggot fly, R. pomonella, from …

[PDF][PDF] Nocturnal behavior in Euapta godeffroyi (accordion sea cucumber): the effects of light exposure and time of day

C Kohnert, S Mason - Independent Research Projects - faculty.aceveda.wwu.edu
Understanding the mechanisms by which biological systems function is essential to conservation
of ecosystems, especially delicate ones like coral reefs. One aspect that needs to be …

Data from: Large‐scale molecular diet analysis in a generalist marine mammal reveals male preference for prey of conservation concern

D Schwarz, SM Spitzer, AC Thomas, CM Kohnert… - 2021 - borealisdata.ca
Sex‐specific diet information is important in the determination of predator impacts on prey
populations. Unfortunately, the diet of males and females can be difficult to describe, …

[PDF][PDF] Improving diagnostic yield in a large inherited retinal dystrophy cohort with high-throughput, NGS-based CNV calling--a clinical evaluation of detection criteria …

NK Wang, J Duan, C Kohnert, G Goh… - … & Visual Science, 2019 - molecularvisionlab.com
Purpose Although advances in computational tools have enabled the identification of copy
number variants (CNVs) from next-generation sequencing (NGS) data, specific criteria for …

How low can you go (and live): Determining the sub-lethal exposure time to desiccation in snowberry maggot flies (Rhagoletis zephyria)

A Klimke, AM Yanny - 2018 - cedar.wwu.edu
Western CEDAR - Scholars Week: How low can you go (and live): Determining the sub-lethal
exposure time to desiccation in snowberry maggot flies (Rhagoletis zephyria) Home …