Antibody optimization enabled by artificial intelligence predictions of binding affinity and naturalness
…, JM Gutierrez, E Yassine, B Medjo, V Blay, C Kohnert… - BioRxiv, 2022 - biorxiv.org
Traditional antibody optimization approaches involve screening a small subset of the
available sequence space, often resulting in drug candidates with suboptimal binding affinity, …
available sequence space, often resulting in drug candidates with suboptimal binding affinity, …
Unlocking de novo antibody design with generative artificial intelligence
Generative artificial intelligence (AI) has the potential to greatly increase the speed, quality
and controllability of antibody design. Traditional de novo antibody discovery requires time …
and controllability of antibody design. Traditional de novo antibody discovery requires time …
Large‐scale molecular diet analysis in a generalist marine mammal reveals male preference for prey of conservation concern
…, SM Spitzer, AC Thomas, CM Kohnert… - Ecology and …, 2018 - Wiley Online Library
Sex‐specific diet information is important in the determination of predator impacts on prey
populations. Unfortunately, the diet of males and females can be difficult to describe, …
populations. Unfortunately, the diet of males and females can be difficult to describe, …
Deep learning-based codon optimization with large-scale synonymous variant datasets enables generalized tunable protein expression
…, H Carter, AB Ventura, MTM Louie, C Kohnert… - bioRxiv, 2023 - biorxiv.org
Increasing recombinant protein expression is of broad interest in industrial biotechnology,
synthetic biology, and basic research. Codon optimization is an important step in heterologous …
synthetic biology, and basic research. Codon optimization is an important step in heterologous …
In vitro validated antibody design against multiple therapeutic antigens using generative inverse folding
…, D Chapman, R Consbruck, A Jaeger, C Kohnert… - bioRxiv, 2023 - biorxiv.org
Deep learning approaches have demonstrated the ability to design protein sequences given
backbone structures [1, 2, 3, 4, 5]. While these approaches have been applied in silico to …
backbone structures [1, 2, 3, 4, 5]. While these approaches have been applied in silico to …
Physiological Mechanisms of Desiccation Resistance in Fruit-Parasitic Rhagoletis Flies
CM Kohnert - 2017 - cedar.wwu.edu
Understanding drought adaptation in fruit-parasitic Rhagoletis flies is essential for evaluating
the potential for eastward spread of the invasive apple maggot fly, R. pomonella, from …
the potential for eastward spread of the invasive apple maggot fly, R. pomonella, from …
[PDF][PDF] Nocturnal behavior in Euapta godeffroyi (accordion sea cucumber): the effects of light exposure and time of day
C Kohnert, S Mason - Independent Research Projects - faculty.aceveda.wwu.edu
Understanding the mechanisms by which biological systems function is essential to conservation
of ecosystems, especially delicate ones like coral reefs. One aspect that needs to be …
of ecosystems, especially delicate ones like coral reefs. One aspect that needs to be …
Data from: Large‐scale molecular diet analysis in a generalist marine mammal reveals male preference for prey of conservation concern
Sex‐specific diet information is important in the determination of predator impacts on prey
populations. Unfortunately, the diet of males and females can be difficult to describe, …
populations. Unfortunately, the diet of males and females can be difficult to describe, …
[PDF][PDF] Improving diagnostic yield in a large inherited retinal dystrophy cohort with high-throughput, NGS-based CNV calling--a clinical evaluation of detection criteria …
NK Wang, J Duan, C Kohnert, G Goh… - … & Visual Science, 2019 - molecularvisionlab.com
Purpose Although advances in computational tools have enabled the identification of copy
number variants (CNVs) from next-generation sequencing (NGS) data, specific criteria for …
number variants (CNVs) from next-generation sequencing (NGS) data, specific criteria for …
How low can you go (and live): Determining the sub-lethal exposure time to desiccation in snowberry maggot flies (Rhagoletis zephyria)
A Klimke, AM Yanny - 2018 - cedar.wwu.edu
Western CEDAR - Scholars Week: How low can you go (and live): Determining the sub-lethal
exposure time to desiccation in snowberry maggot flies (Rhagoletis zephyria) Home …
exposure time to desiccation in snowberry maggot flies (Rhagoletis zephyria) Home …