Cohesin is a chromatin-associated protein complex that mediates sister chromatid cohesion
by connecting replicated DNA molecules. Cohesin also has important roles in gene …

Formation of the three primary germ layers during gastrulation is an essential step in the
establishment of the vertebrate body plan and is associated with major transcriptional changes …

Long noncoding RNAs are implicated in a number of regulatory functions in eukaryotic
genomes. The paternally expressed long noncoding RNA (ncRNA)Kcnq1ot1 regulates …

Mouse embryonic stem cells are dynamic and heterogeneous. For example, rare cells cycle
through a state characterized by decondensed chromatin and expression of transcripts, …

The molecular regulation of zygotic genome activation (ZGA) in mammals remains an
exciting area of research. Primed mouse embryonic stem cells contain a rare subset of “2C-like” …

DNA methylation is a repressive epigenetic modification that is essential for development,
exemplified by the embryonic and perinatal lethality observed in mice lacking de novo DNA …

The unfolded protein response of the endoplasmic reticulum (UPR ER ) is a crucial mediator
of secretory pathway homeostasis. Expression of the spliced and active form of the UPR ER …

10.7554/eLife.34081.001 Transcription of protein coding genes is accompanied by recruitment
of COMPASS to promoter-proximal chromatin, which methylates histone H3 lysine 4 (…

The transition from naive to primed pluripotency is accompanied by an extensive reorganisation
of transcriptional and epigenetic programmes. However, the role of transcriptional …

Germinal centres (GCs) are T follicular helper cell (Tfh)-dependent structures that form in
response to vaccination, producing long-lived antibody secreting plasma cells and memory B …