Genome-wide association analysis of cohorts with thousands of phenotypes is computationally
expensive, particularly when accounting for sample relatedness or population structure. …

A major goal in human genetics is to use natural variation to understand the phenotypic
consequences of altering each protein-coding gene in the genome. Here we used exome …

During the past few years, various novel statistical methods have been developed for fine-mapping
with the use of summary statistics from genome-wide association studies (GWASs). …

Widespread linkage disequilibrium and incomplete annotation of cell-to-cell state variation
represent substantial challenges to elucidating mechanisms of trait-associated genetic …

Clinical laboratory tests are a critical component of the continuum of care. We evaluate the
genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n = 363,228 …

Motivation: The goal of fine-mapping in genomic regions associated with complex diseases
and traits is to identify causal variants that point to molecular mechanisms behind the …

INTRODUCTION Obesity accounts for a substantial and growing burden of disease globally.
Body adiposity is highly heritable, and human genetic studies can lead to biological and …

The Pharma Proteomics Project is a precompetitive biopharmaceutical consortium characterizing
the plasma proteomic profiles of 54,219 UK Biobank participants. Here we provide a …

Migraine affects over a billion individuals worldwide but its genetic underpinning remains
largely unknown. Here, we performed a genome-wide association study of 102,084 migraine …

Fine-mapping aims to identify causal variants impacting complex traits. We propose PolyFun,
a computationally scalable framework to improve fine-mapping accuracy by leveraging …