… CC Yost reports a grant from PEEL Therapeutics, Inc. during the conduct of the study; in
addition, CC Yost authors a US patent (patent no. 10,232,023 B2) held by the University of Utah …

There is an urgent need to understand the pathogenesis of coronavirus disease 2019 (COVID-19).
In particular, thrombotic complications in patients with COVID-19 are common and …

Platelets are specialized hemostatic cells that circulate in the blood as anucleate cytoplasts.
We report that platelets unexpectedly possess a functional spliceosome, a complex that …

Inbred mice are a useful tool for studying the in vivo functions of platelets. Nonetheless, the
mRNA signature of mouse platelets is not known. Here, we use paired-end next-generation …

Neutrophils are highly specialized innate effector cells that have evolved for killing of pathogens.
Human neonates have a common multifactorial syndrome of neutrophil dysfunction that …

Human β-defensins (hBD) are antimicrobial peptides that curb microbial activity. Although
hBD's are primarily expressed by epithelial cells, we show that human platelets express hBD-…

Neutrophils are highly specialized innate immune effector cells that evolved for antimicrobial
host defense. In response to inflammatory stimuli and pathogens, they form neutrophil …

The platelet-activating factor (PAF) signaling cascade evolved as a component of the repertoire
of innate host defenses, but is also an effector pathway in inflammatory and thrombotic …

Neutrophil granulocytes, also called polymorphonuclear leukocytes (PMNs), extrude
molecular lattices of decondensed chromatin studded with histones, granule enzymes, and …

Ischemic stroke prompts a strong inflammatory response, which is associated with exacerbated
outcomes. In this study, we investigated mechanistic regulators of neutrophil extracellular …