Miro proteins coordinate microtubule‐and actin‐dependent mitochondrial transport and distribution

G López‐Doménech, C CovillCooke… - The EMBO …, 2018 - embopress.org
In the current model of mitochondrial trafficking, Miro1 and Miro2 Rho‐ GTP ases regulate
mitochondrial transport along microtubules by linking mitochondria to kinesin and dynein …

[HTML][HTML] Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery

…, G López-Doménech, EF Halff, C Covill-Cooke… - Nature …, 2019 - nature.com
Mitochondrial Rho (Miro) GTPases localize to the outer mitochondrial membrane and are
essential machinery for the regulated trafficking of mitochondria to defined subcellular locations…

Peroxisomal fission is modulated by the mitochondrial Rho‐GTPases, Miro1 and Miro2

C CovillCooke, VS Toncheva, J Drew, N Birsa… - EMBO …, 2020 - embopress.org
Peroxisomes are essential for a number of cellular functions, including reactive oxygen
species metabolism, fatty acid β‐oxidation and lipid synthesis. To ensure optimal functionality, …

Expanding the CRISPR imaging toolset with Staphylococcus aureus Cas9 for simultaneous imaging of multiple genomic loci

…, H Liu, S Balakrishnan, C Covill-Cooke… - Nucleic acids …, 2016 - academic.oup.com
In order to elucidate the functional organization of the genome, it is vital to directly visualize
the interactions between genomic elements in living cells. For this purpose, we engineered …

Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response

…, JH Howden, C CovillCooke… - The EMBO …, 2021 - embopress.org
Clearance of mitochondria following damage is critical for neuronal homeostasis. Here, we
investigate the role of Miro proteins in mitochondrial turnover by the PINK1/Parkin …

Shared structural features of Miro binding control mitochondrial homeostasis

C Covill-Cooke, B Kwizera, G López-Doménech… - The EMBO …, 2024 - embopress.org
Miro proteins are universally conserved mitochondrial calcium-binding GTPases that regulate
a multitude of mitochondrial processes, including transport, clearance, and lipid trafficking. …

[HTML][HTML] Regulation of peroxisomal trafficking and distribution

C Covill-Cooke, VS Toncheva, JT Kittler - Cellular and Molecular Life …, 2021 - Springer
Peroxisomes are organelles that perform a wide range of essential metabolic processes. To
ensure that peroxisomes are optimally positioned in the cell, they must be transported by …

Ubiquitination at the mitochondria in neuronal health and disease

C Covill-Cooke, JH Howden, N Birsa… - Neurochemistry …, 2018 - Elsevier
The preservation of mitochondrial function is of particular importance in neurons given the
high energy requirements of action potential propagation and synaptic transmission. Indeed, …

[PDF][PDF] A mechanism to PLAse the eye

C Covill-Cooke, B Kornmann - Developmental Cell, 2021 - cell.com
Christian Covill-Cooke1,* and Benoıt Kornmann1,* 1Department of Biochemistry,
University of Oxford, South Parks Road, Oxford, OX1 3QU, UK *Correspondence: christian.covill-cooke@bioch.ox.ac.uk …

Miro ubiquitination is critical for efficient damage-induced PINK1/Parkin-mediated mitophagy

G López-Doménech, C Covill-Cooke, JH Howden… - BioRxiv, 2018 - biorxiv.org
Clearance of mitochondria following damage is critical for neuronal homeostasis. Here, we
investigate the role of Miro proteins in mitochondrial turnover by the PINK1 / Parkin …