Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

Aging is a progressive process determined by genetic and acquired factors. Among the
latter are the chemical reactions referred to as nonenzymatic posttranslational modifications (…

Although it has long been established that the extracellular matrix acts as a mechanical
support, its degradation products, which mainly accumulate during aging, have also been …

Skin aging is characterized by different features including wrinkling, atrophy of the dermis
and loss of elasticity associated with damage to the extracellular matrix protein elastin. The …

MHC class I peptides are products of endogenous cellular protein degradation. Their prompt
presentation, after rapid degradation of their newly synthesized source proteins, is needed …

Elastic fibers are extracellular components of higher vertebrates and confer elasticity and
resilience to numerous tissues and organs such as large blood vessels, lungs, and skin. Their …

To provide a basis for the development of approaches to treat elastin‐degrading diseases,
the aim of this study was to investigate the degradation of the natural substrate tropoelastin by …

Cadmium (Cd) is an important environmental pollutant and is poisonous to most organisms.
We aimed to unravel the mechanisms of Cd toxicity in the model water plant Ceratophyllum …

Lysyl oxidases (LOXs) play a central role in extracellular matrix remodeling during development
and tumor growth and fibrosis through cross-linking of collagens and elastin. We have …

Elastin is an essential vertebrate protein responsible for the elasticity of force-bearing tissues
such as those of the lungs, blood vessels, and skin. One of the key features required for the …