Fumarate hydratase (FH) is an enzyme of the tricarboxylic acid cycle (TCA cycle) that
catalyses the hydration of fumarate into malate. Germline mutations of FH are responsible for …

Ischaemia-reperfusion injury occurs when the blood supply to an organ is disrupted and then
restored, and underlies many disorders, notably heart attack and stroke. While reperfusion …

Mutations of the tricarboxylic acid cycle enzyme fumarate hydratase cause hereditary
leiomyomatosis and renal cell cancer 1 . Fumarate hydratase-deficient renal cancers are highly …

Mechanical forces shape cells and tissues during development and adult homeostasis. In
addition, they also signal to cells via mechanotransduction pathways to control cell proliferation…

Metabolic reprogramming has become a key focus for both immunologists and cancer biologists,
with exciting advances providing new insights into the mechanisms underlying disease…

Mitochondria participate in key metabolic reactions of the cell and regulate crucial signaling
pathways including apoptosis. Although several approaches are available to study …

Mitochondria amplify activation of caspases during apoptosis by releasing cytochrome c and
other cofactors. This is accompanied by fragmentation of the organelle and remodeling of …

Activated macrophages undergo metabolic reprogramming, which drives their pro-inflammatory
phenotype, but the mechanistic basis for this remains obscure. Here, we demonstrate …

The endogenous metabolite itaconate has recently emerged as a regulator of macrophage
function, but its precise mechanism of action remains poorly understood 1 , 2 , 3 . Here we …

Respiratory chain complexes assemble into functional quaternary structures called
supercomplexes (RCS) within the folds of the inner mitochondrial membrane, or cristae. Here, we …