The distinct protein aggregates that are found in Alzheimer's, Parkinson's, Huntington's and
prion diseases seem to cause these disorders. Small intermediates — soluble oligomers — …

Microglia play a pivotal role in the maintenance of brain homeostasis but lose homeostatic
function during neurodegenerative disorders. We identified a specific apolipoprotein E (APOE)…

ALZHEIMER'S disease is characterized by the extracellular deposition in the brain and its
blood vessels of insoluble aggregates of the amyloid β-peptide (Aβ), a fragment, of about 40 …

The neurodegeneration observed in Alzheimer's disease has been associated with synaptic
dismantling and progressive decrease in neuronal activity. We tested this hypothesis in vivo …

PROGRESSIVE cerebral deposition of the 39–43-amino-acid amy-loid β-protein (Aβ) is an
invariant feature of Alzheimer's disease which precedes symptoms of dementia by years or …

γ-Secretase is a membrane protein complex with an unusual aspartyl protease activity that
catalyses the regulated intramembranous cleavage of the β-amyloid precursor protein (APP) …

Amyloid β peptide (Aβ), the principal proteinaceous component of amyloid plaques in brains
of Alzheimer’s disease patients, is derived by proteolytic cleavage of the amyloid precursor …

We have generated a novel transgenic mouse model on a C57BL/6J genetic background
that coexpresses KM670/671NL mutated amyloid precursor protein and L166P mutated …

Although BACE1 (beta-site amyloid precursor protein–cleaving enzyme 1) is essential for the
generation of amyloid-b peptide in Alzheimer's disease, its physiological function is unclear…

Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." …