[HTML][HTML] Accurate whole human genome sequencing using reversible terminator chemistry

…, NF Hansen, K Harnish, CD Haudenschild… - nature, 2008 - nature.com
DNA sequence information underpins genetic research, enabling discoveries of important
biological or medical benefit. Sequencing projects have traditionally used long (400–800 …

Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning

…, X Zhang, Z Chen, B Merriman, CD Haudenschild… - Nature, 2008 - nature.com
Cytosine DNA methylation is important in regulating gene expression and in silencing
transposons and other repetitive sequences 1 , 2 . Recent genomic studies in Arabidopsis …

[HTML][HTML] A comprehensive catalogue of somatic mutations from a human cancer genome

…, NA Gormley, RJ Grocock, CD Haudenschild… - Nature, 2010 - nature.com
All cancers carry somatic mutations. A subset of these somatic alterations, termed driver
mutations, confer selective growth advantage and are implicated in cancer development, …

Angiogenesis in vitro

J Folkman, C Haudenschild - Nature, 1980 - nature.com
Cloned capillary endothelial cells, cultured in tumour-conditioned medium, form capillary
tubes. By light and electron microscopy these tubes resemble capillaries in vivo. This first …

[HTML][HTML] Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice

…, OC Trifan, MT Wu, E Smith, C Haudenschild… - Journal of Biological …, 2001 - ASBMB
The cyclooxygenase (COX)-2 gene encodes an inducible prostaglandin synthase enzyme
that is overexpressed in adenocarcinomas and other tumors. Deletion of the murine Cox-2 …

Long-term culture of capillary endothelial cells.

J Folkman, CC Haudenschild… - Proceedings of the …, 1979 - National Acad Sciences
Capillary endothelial cells from rats, calves, and humans, have been carried in long-term
culture. Bovine capillary endothelial cells have been cloned and maintained by serial passage …

BAP1 loss defines a new class of renal cell carcinoma

…, N Grishin, M Laurent, XJ Xie, CD Haudenschild… - Nature …, 2012 - nature.com
The molecular pathogenesis of renal cell carcinoma (RCC) is poorly understood. Whole-genome
and exome sequencing followed by innovative tumorgraft analyses (to accurately …

[HTML][HTML] Genome evolution in the allotetraploid frog Xenopus laevis

…, C Takagi, R Heald, K Miller, C Haudenschild… - Nature, 2016 - nature.com
To explore the origins and consequences of tetraploidy in the African clawed frog, we sequenced
the Xenopus laevis genome and compared it to the related diploid X. tropicalis genome…

Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone

J Folkman, R Langer, RJ Linhardt, C Haudenschild… - Science, 1983 - science.org
Heparin or a heparin fragment administered with cortisone inhibited angiogenesis, caused
regression of large tumor masses, and prevented metastases. Oral administration of heparin …

Elucidation of the small RNA component of the transcriptome

C Lu, SS Tej, S Luo, CD Haudenschild, BC Meyers… - Science, 2005 - science.org
Small RNAs play important regulatory roles in most eukaryotes, but only a small proportion
of these molecules have been identified. We sequenced more than two million small RNAs …