One of the problems associated with the large-scale analysis of unannotated, low quality
EST sequences is the detection of coding regions and the correction of frameshift errors that …

Many approaches to identify therapeutically relevant neoantigens couple tumor sequencing
with bioinformatic algorithms and inferred rules of tumor epitope immunogenicity. However, …

We performed exome sequencing to detect somatic mutations in protein-coding regions in
seven melanoma cell lines and donor-matched germline cells. All melanoma samples had …

We conducted a pilot clinical trial testing a personalized vaccine generated by autologous
dendritic cells (DCs) pulsed with oxidized autologous whole-tumor cell lysate (OCDC), which …

Narcolepsy with cataplexy is a sleep disorder caused by deficiency in the hypothalamic
neuropeptide hypocretin/orexin (HCRT), unanimously believed to result from autoimmune …

Transcripts with ESTs derived exclusively or predominantly from testis, and not from other
normal tissues, are likely to be products of genes with testis-restricted expression, and are thus …

Massively parallel signature sequencing (MPSS) generates millions of short sequence tags
corresponding to transcripts from a single RNA preparation. Most MPSS tags can be …

Immunotherapy directed against private tumor neo-antigens derived from non-synonymous
somatic mutations is a promising strategy of personalized cancer immunotherapy. However, …

Because plants do not possess a defined germline, deleterious somatic mutations can be
passed to gametes, and a large number of cell divisions separating zygote from gamete …

We have used massively parallel signature sequencing (MPSS) to sample the transcriptomes
of 32 normal human tissues to an unprecedented depth, thus documenting the patterns of …