Mammalian cells harbor more than a thousand RNA-binding proteins (RBPs), with half of
these employing unknown modes of RNA binding. We developed RBDmap to determine the …

Over the past decade peptide sequencing by collision induced dissociation (CID) has
become the method of choice in mass spectrometry-based proteomics. The development of …

Increasing peptide sequence coverage by tandem mass spectrometry improves confidence
in database search-based peptide identification and facilitates mapping of post-translational …

We recently introduced a novel scheme combining electron-transfer and higher-energy
collision dissociation (termed EThcD), for improved peptide ion fragmentation and identification. …

The identification of peptides presented by human leukocyte antigen (HLA) class I is tremendously
important for the understanding of antigen presentation mechanisms under healthy or …

An essential and so far unresolved factor influencing the evolution of cancer and the clinical
management of patients is intratumour clonal and phenotypic heterogeneity. However, the …

The maternal-to-zygotic transition (MZT) is a process that occurs in animal embryos at the
earliest developmental stages, during which maternally deposited mRNAs and other …

Regulation of the turnover of complex I (CI), the largest mitochondrial respiratory chain
complex, remains enigmatic despite huge advancement in understanding its structure and the …

Several quantitative mass spectrometry based technologies have recently evolved to interrogate
the complexity, interconnectivity and dynamic nature of proteomes. Currently, the most …

Astrocytes have emerged for playing important roles in brain tissue repair; however, the
underlying mechanisms remain poorly understood. We show that acute injury and blood-brain …