A limiting factor in membrane protein research is the ability to solubilize and stabilize such
proteins. Detergents are used most often for solubilizing membrane proteins, but they are …

Members of the major facilitator superfamily (MFS) of transport proteins are essential for the
movement of a wide range of substrates across biomembranes. As this transport requires a …

The coronavirus SARS-CoV-2 is the cause of the ongoing COVID-19 pandemic. Therapeutic
neutralizing antibodies constitute a key short-to-medium term approach to tackle COVID-19. …

Here we present two structures of the major facilitator (MFS) xylose transporter XylE from
Escherichia coli in inward open and partially occluded inward open conformations. These …

The uptake of peptides in mammals plays a crucial role in nutrition and inflammatory
diseases. This process is mediated by promiscuous transporters of the solute carrier family 15, …

Protein stability in detergent or membrane-like environments is the bottleneck for structural
studies on integral membrane proteins (IMP). Irrespective of the method to study the structure …

Saposin-derived lipid nanoparticles (SapNPs) are a new alternative tool for membrane protein
reconstitution. Here we demonstrate the potential and advantages of SapNPs. We show …

Short‐chain peptides are transported across membranes through promiscuous proton‐dependent
oligopeptide transporters (POTs)—a subfamily of the major facilitator superfamily (MFS…

Peptide transporters of the PepT family have key roles in the transport of di- and tripeptides
across membranes as well as in the absorption of orally administered drugs in the small …

The Escherichia coli peptide binding protein OppA is an essential component of the oligopeptide
transporter Opp. Based on studies on its orthologue from Salmonella typhimurium, it …