Protein interactions regulate the systems-level behavior of cells; thus, deciphering the structure
and dynamics of protein interaction networks in their cellular context is a central goal in …

The mutation process ultimately defines the genetic features of all populations and, hence,
has a bearing on a wide range of issues involving evolutionary genetics, inheritance, and …

Previous studies in Saccharomyces cerevisiae have demonstrated that cryptic promoters
within coding regions activate transcription in particular mutants. We have performed a …

Identifying the properties of gene networks that influence their evolution is a fundamental
research goal. However, modes of evolution cannot be inferred solely from the distribution of …

Owing to their crucial roles in regulating protein function, phosphorylation sites (phosphosites)
are expected to be evolutionarily conserved. However, mixed results regarding this …

Hybrids between species are often characterized by novel gene-expression patterns. A
recent study on allele-specific gene expression in hybrids between species of Drosophila …

Hybridization is recognized as a powerful mechanism of speciation and a driving force in
generating biodiversity. However, only few multicellular species, limited to a handful of plants …

Saccharomyces cerevisiae, the budding yeast, is the most thoroughly studied eukaryote at
the cellular, molecular, and genetic levels. Yet, until recently, we knew very little about its …

Amoeba use phagocytosis to internalize bacteria as a source of nutrients, whereas
multicellular organisms utilize this process as a defense mechanism to kill microbes and, in …

Atlantic salmon (Salmo salar) undergo spectacular marine migrations before homing to
spawn in natal rivers. However, males that grow fastest early in life can adopt an alternative ‘…