GABAergic control of substantia nigra dopaminergic neurons
At least 70% of the afferents to substantia nigra dopaminergic neurons are GABAergic. The
vast majority of these arise from the neostriatum, the external globus pallidus and the …
vast majority of these arise from the neostriatum, the external globus pallidus and the …
[HTML][HTML] Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward
Insulin activates insulin receptors (InsRs) in the hypothalamus to signal satiety after a meal.
However, the rising incidence of obesity, which results in chronically elevated insulin levels, …
However, the rising incidence of obesity, which results in chronically elevated insulin levels, …
Aberrant cortical activity in multiple GCaMP6-expressing transgenic mouse lines
Transgenic mouse lines are invaluable tools for neuroscience but, as with any technique,
care must be taken to ensure that the tool itself does not unduly affect the system under study. …
care must be taken to ensure that the tool itself does not unduly affect the system under study. …
Mitochondria are the source of hydrogen peroxide for dynamic brain-cell signaling
Hydrogen peroxide (H 2 O 2 ) is emerging as a ubiquitous small-molecule messenger in
biology, particularly in the brain, but underlying mechanisms of peroxide signaling remain an …
biology, particularly in the brain, but underlying mechanisms of peroxide signaling remain an …
Intrinsic and integrative properties of substantia nigra pars reticulata neurons
FM Zhou, CR Lee - Neuroscience, 2011 - Elsevier
The GABA projection neurons of the substantia nigra pars reticulata (SNr) are output
neurons for the basal ganglia and thus critical for movement control. Their most striking …
neurons for the basal ganglia and thus critical for movement control. Their most striking …
Cell type-specific differences in chloride-regulatory mechanisms and GABAA receptor-mediated inhibition in rat substantia nigra
The regulation of intracellular chloride has important roles in neuronal function, especially
by setting the magnitude and direction of the Cl - flux gated by GABA A receptors. Previous …
by setting the magnitude and direction of the Cl - flux gated by GABA A receptors. Previous …
[HTML][HTML] Measuring the health of an invisible population: lessons from the Colorado Transgender Health Survey
R Christian, AA Mellies, AG Bui, R Lee, L Kattari… - Journal of general …, 2018 - Springer
Background Transgender people, those whose gender identity does not match their sex
assigned at birth, face barriers to receiving health care. These include discrimination, prohibitive …
assigned at birth, face barriers to receiving health care. These include discrimination, prohibitive …
[BOOK][B] Basal ganglia control of substantia nigra dopaminergic neurons
Although substantia nigra dopaminergic neurons are spontaneously active both in vivo and
in vitro, this activity does not depend on afferent input as these neurons express an …
in vitro, this activity does not depend on afferent input as these neurons express an …
Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis
SD McAllister, R Murase, RT Christian, D Lau… - Breast cancer research …, 2011 - Springer
Invasion and metastasis of aggressive breast cancer cells are the final and fatal steps during
cancer progression. Clinically, there are still limited therapeutic interventions for aggressive …
cancer progression. Clinically, there are still limited therapeutic interventions for aggressive …
Cannabidiol Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
The cannabinoid 1 (CB 1 ) and cannabinoid 2 (CB 2 ) receptor agonist Δ 9 -tetrahydrocannabinol
(THC) has been shown to be a broad-range inhibitor of cancer in culture and in vivo, …
(THC) has been shown to be a broad-range inhibitor of cancer in culture and in vivo, …