Proteasome inhibitors are used to treat blood cancers such as multiple myeloma (MM) and
mantle cell lymphoma. The efficacy of these drugs is frequently undermined by acquired …

Serine hydrolases play diverse roles in regulating host–pathogen interactions in a number
of organisms, yet few have been characterized in the human pathogen Staphylococcus …

Although serine proteases are important mediators of Mycobacterium tuberculosis (Mtb)
virulence, there are currently no tools to selectively block or visualize members of this family of …

Phenotypically distinct cellular (sub)populations are clinically relevant for the virulence and
antibiotic resistance of a bacterial pathogen, but functionally different cells are usually …

The development of new treatment options for bacterial infections requires access to new
targets for antibiotics and antivirulence strategies. Chemoproteomic approaches are powerful …

Chemical probes have been instrumental in microbiology since its birth as a discipline in the
19th century when chemical dyes were used to visualize structural features of bacterial cells …

The bacterial genus Staphylococcus comprises diverse species that colonize the skin as
commensals but can also cause infection. Previous work identified a family of serine hydrolases …

Lymphatic filariasis and onchocerciasis are severe diseases caused by filarial worms and
affect more than 150 million people worldwide. Endosymbiotic α-proteobacteria Wolbachia …

Staphylococcus aureus is a prevalent bacterial pathogen in both community and hospital
settings, and its treatment is made particularly difficult by resilience within biofilms. Within this …

Activity‐based protein profiling is a powerful chemoproteomic technique to detect active
enzymes and identify targets and off‐targets of drugs. Here, we report the use of carmofur‐ and …