Inflammatory bowel disease (IBD) typically manifests as either ulcerative colitis (UC) or
Crohn's disease (CD). Systematic identification of susceptibility genes for IBD has thus far …

Nonalcoholic fatty liver disease (NAFLD), a common prelude to cirrhosis and hepatocellular
carcinoma, is the most common chronic liver disease worldwide. Defining the molecular …

Molecular danger signals attract neutrophilic granulocytes (polymorphonuclear leukocytes (PMNs))
to sites of infection. The G protein-coupled receptor (GPR) 43 recognizes propionate …

The complement system is part of innate sensor and effector systems such as the Toll-like
receptors (TLRs). It recognizes and quickly systemically and/or locally respond to microbial-…

Recent advances have enabled a comprehensive understanding of the genetic architecture
of inflammatory bowel disease (IBD) with over 30 identified and replicated disease loci. The …

Objective The mammalian commensal gut microbiota is highly diverse and displays an
individual-specific composition determined by host genotype and environmental factors. The …

The protease a disintegrin and metalloprotease (ADAM) 17 cleaves tumor necrosis factor (TNF),
L-selectin, and epidermal growth factor receptor (EGF-R) ligands from the plasma …

Although a great variety of new drugs have been introduced for the therapy of inflammatory
bowel diseases so far, a definite cure of the disease is still out of scope. An anti-inflammatory …

We performed a genome-wide association analysis of 1,897,764 SNPs in 1,043 German
ulcerative colitis (UC) cases and 1,703 controls. We discovered new associations at …

Generation of microbicidal reactive oxygen species (ROS) is a pivotal protective component
of the innate immune system in many eukaryotes. NOD (nucleotide oligomerisation domain …