Background: Previously, small studies have found that BRCA1 and BRCA2 breast tumors
differ in their pathology. Analysis of larger datasets of mutation carriers should allow further …

Background: Data for multiple common susceptibility alleles for breast cancer may be combined
to identify women at different levels of breast cancer risk. Such stratification could guide …

Importance Limited information about the relationship between specific mutations
inBRCA1orBRCA2(BRCA1/2) and cancer risk exists. Objective To identify mutation-specific cancer …

Germline BRCA1 mutations predispose to breast cancer. To identify genetic modifiers of this
risk, we performed a genome-wide association study in 1,193 individuals with BRCA1 …

Background Medulloblastoma is associated with rare hereditary cancer predisposition
syndromes; however, consensus medulloblastoma predisposition genes have not been defined …

The large diversity of central nervous system (CNS) tumor types in children and adolescents
results in disparate patient outcomes and renders accurate diagnosis challenging. In this …

PURPOSE To provide precise age-specific risk estimates of cancers other than female breast
and ovarian cancers associated with pathogenic variants (PVs) in BRCA1 and BRCA2 for …

Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC)
susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 and …

Germline mutations in BRCA1 and BRCA2 confer high risks of breast cancer. However,
evidence suggests that these risks are modified by other genetic or environmental factors that …

The ‘Individualized Therapy for Relapsed Malignancies in Childhood’ (INFORM) precision
medicine study is a nationwide German program for children with high-risk relapsed/refractory …