Epigenetic regulation of gene expression, through covalent modification of histones, is a
key process controlling growth and development. Accordingly, the transcription factors …

Seckel syndrome is a heterogeneous, autosomal recessive disorder marked by prenatal
proportionate short stature, severe microcephaly, intellectual disability, and characteristic facial …

Shape memory alloys (SMAs) are often used as actuators in articulated miniature devices.
These devices typically use multiple actuators to achieve multiple degrees of articulation. The …

Multiple sclerosis (MS) is the most frequent demyelinating disease and a leading cause for
disability in young adults. Despite significant advances in immunotherapies in recent years, …

The cell cycle is a temporal program that regulates DNA synthesis and cell division. When
we compared the codon usage of cell cycle‐regulated genes with that of other genes, we …

TrmD and Trm5 are, respectively, the bacterial and eukarya/archaea methyl transferases
that catalyze transfer of the methyl group from S-adenosyl methionine (AdoMet) to the N1 …

N1-methylation of G37 is required for a subset of tRNAs to maintain the translational reading-frame.
While loss of m1G37 increases ribosomal+ 1 frameshifting, whether it incurs …

The enzyme tRNA(m1G37) methyltransferase catalyzes the transfer of a methyl group from S-adenosyl-l-methionine
(AdoMet) to the N1 position of G37 in the anticodon loop of a subset …

Mg 2+ is required for the catalytic activity of TrmD, a bacteria-specific methyltransferase that
is made up of a protein topological knot-fold, to synthesize methylated m 1 G37-tRNA to …

Enzymes that use distinct active site structures to perform identical reactions are known as
analogous enzymes. The isolation of analogous enzymes suggests the existence of multiple …