User profiles for Christian Vanhove

Christian Vanhove

Institute Biomedical Technology - Medical Imaging and Signal Processing
Verified email at UGent.be
Cited by 7029

Phase I study of 68Ga-HER2-nanobody for PET/CT assessment of HER2 expression in breast carcinoma

…, C Fontaine, I Vaneycken, C Vanhove… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Human epidermal growth factor receptor 2 (HER2) status is one of the major tumor characteristics
in breast cancer to guide therapy. Anti-HER2 treatment has clear survival advantages …

Comparison of the biodistribution and tumor targeting of two 99mTc-labeled anti-EGFR nanobodies in mice, using pinhole SPECT/micro-CT

…, S Hernot, I Vaneycken, C Vanhove… - Journal of Nuclear …, 2008 - Soc Nuclear Med
Camelidae possess an unusual class of antibodies devoid of light chains. Nanobodies are
intact antigen-binding fragments that are stable, easily generated against different targets, …

Review of SPECT collimator selection, optimization, and fabrication for clinical and preclinical imaging

…, R Van Holen, S Vandenberghe, C Vanhove… - Medical …, 2015 - Wiley Online Library
In single photon emission computed tomography, the choice of the collimator has a major
impact on the sensitivity and resolution of the system. Traditional parallel‐hole and fan‐beam …

Localization, mechanism and reduction of renal retention of technetium‐99m labeled epidermal growth factor receptor‐specific nanobody in mice

…, V Caveliers, N Devoogdt, C Vanhove… - Contrast media & …, 2011 - Wiley Online Library
Background Nanobodies are single‐domain antigen binding fragments derived from
functional heavy‐chain antibodies elicited in Camelidae. They are powerful probes for …

Cancer-associated adipose tissue promotes breast cancer progression by paracrine oncostatin M and Jak/STAT3 signaling

…, R Limame, P Mestdagh, J Vandesompele, C Vanhove… - Cancer research, 2014 - AACR
Increasing evidence supports the critical roles played by adipose tissue in breast cancer
progression. Yet, the mediators and mechanisms are poorly understood. Here, we show that …

Radiotherapy-activated cancer-associated fibroblasts promote tumor progression through paracrine IGF1R activation

…, J Leenders, B Descamps, A Debucquoy, C Vanhove… - Cancer research, 2018 - AACR
Preoperative radiotherapy (RT) is a mainstay in the management of rectal cancer, a tumor
characterized by desmoplastic stroma containing cancer-associated fibroblasts (CAF). …

[HTML][HTML] ESTRO ACROP: Technology for precision small animal radiotherapy research: Optimal use and challenges

…, KM Prise, D Sarrut, D Thorwarth, C Vanhove… - Radiotherapy and …, 2018 - Elsevier
Many radiotherapy research centers have recently installed novel research platforms enabling
the investigation of the radiation response of tumors and normal tissues in small animal …

Co-delivery of nucleoside-modified mRNA and TLR agonists for cancer immunotherapy: Restoring the immunogenicity of immunosilent mRNA

…, M Van Bockstal, B Descamps, C Vanhove… - Journal of Controlled …, 2017 - Elsevier
This study reports on the design of mRNA and adjuvant-loaded lipid nanoparticles for
therapeutic cancer vaccination. The use of nucleoside-modified mRNA has previously been …

Sortase A‐mediated site‐specific labeling of camelid single‐domain antibody‐fragments: a versatile strategy for multiple molecular imaging modalities

…, J Steyaert, B Descamps, C Vanhove… - Contrast media & …, 2016 - Wiley Online Library
A generic site‐specific conjugation method that generates a homogeneous product is of
utmost importance in tracer development for molecular imaging and therapy. We explored the …

Angiopoietin‐2 promotes pathological angiogenesis and is a therapeutic target in murine nonalcoholic fatty liver disease

…, S Neyt, B Vandeghinste, C Vanhove… - …, 2019 - Wiley Online Library
Angiogenesis contributes to the development of nonalcoholic steatohepatitis (NASH) and
promotes inflammation, fibrosis, and progression to hepatocellular carcinoma (HCC). …