User profiles for Christian Wozny

Christian Wozny

MSH Medical School Hamburg, Germany
Verified email at medicalschool-hamburg.de
Cited by 2114

[HTML][HTML] A community-based transcriptomics classification and nomenclature of neocortical cell types

…, AS Tolias, MA Tosches, MT García, C Wozny… - Nature …, 2020 - nature.com
To understand the function of cortical circuits, it is necessary to catalog their cellular diversity.
Past attempts to do so using anatomical, physiological or molecular features of cortical …

[HTML][HTML] Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration

EK Wirth, M Conrad, J Winterer, C Wozny… - The FASEB …, 2010 - ncbi.nlm.nih.gov
Cerebral selenium (Se) deficiency is associated with neurological phenotypes including
seizures and ataxia. We wanted to define whether neurons require selenoprotein expression …

Optogenetic acidification of synaptic vesicles and lysosomes

BR Rost, F Schneider, MK Grauel, C Wozny… - Nature …, 2015 - nature.com
Acidification is required for the function of many intracellular organelles, but methods to
acutely manipulate their intraluminal pH have not been available. Here we present a targeting …

[PDF][PDF] Activity-mediated AMPA receptor remodeling, driven by alternative splicing in the ligand-binding domain

AC Penn, A Balik, C Wozny, O Cais, IH Greger - Neuron, 2012 - cell.com
The AMPA-type glutamate receptor (AMPAR) subunit composition shapes synaptic transmission
and varies throughout development and in response to different input patterns. Here, …

Specificity of synaptic connectivity between layer 1 inhibitory interneurons and layer 2/3 pyramidal neurons in the rat neocortex

C Wozny, SR Williams - Cerebral cortex, 2011 - academic.oup.com
Understanding the structure and function of the neocortical microcircuit requires a description
of the synaptic connectivity between identified neuronal populations. Here, we investigate …

Role of amyloid-β glycine 33 in oligomerization, toxicity, and neuronal plasticity

A Harmeier, C Wozny, BR Rost, LM Munter… - Journal of …, 2009 - Soc Neuroscience
The aggregation of the amyloid-β (Aβ) peptide plays a pivotal role in the pathogenesis of
Alzheimer's disease, as soluble oligomers are intimately linked to neuronal toxicity and …

Cellular and network properties of the subiculum in the pilocarpine model of temporal lobe epilepsy

A Knopp, A Kivi, C Wozny… - Journal of …, 2005 - Wiley Online Library
The subiculum was recently shown to be crucially involved in the generation of interictal
activity in human temporal lobe epilepsy. Using the pilocarpine model of epilepsy, this study …

[HTML][HTML] Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesis

…, A Sporbert, D Militz, V Schmidt, C Wozny… - Journal of biological …, 2008 - ASBMB
Sortilin-related receptor with A-type repeats (SORLA) is a sorting receptor that impairs
processing of amyloid precursor protein (APP) to soluble (s) APP and to the amyloid β-peptide in …

[PDF][PDF] Excitatory microcircuits within superficial layers of the medial entorhinal cortex

J Winterer, N Maier, C Wozny, P Beed, J Breustedt… - Cell Reports, 2017 - cell.com
The distinctive firing pattern of grid cells in the medial entorhinal cortex (MEC) supports its
role in the representation of space. It is widely believed that the hexagonal firing field of grid …

Comment on" On the origin of interictal activity in human temporal lobe epilepsy in vitro"

C Wozny, A Kivi, TN Lehmann, C Dehnicke… - Science, 2003 - science.org
For more than a decade, there has been extensive discussion about whether hippocampal
sclerosis causes enhanced neuronal excitability as a prerequisite for seizure generation. The …