Comprehensive protein–protein interaction maps promise to reveal many aspects of the
complex regulatory network underlying cellular function. Recently, large-scale approaches have …

The species complexity of microbial communities and challenges in culturing representative
isolates make it difficult to obtain assembled genomes. Here we characterize and compare …

Interactions between proteins and small molecules are an integral part of biological processes
in living organisms. Information on these interactions is dispersed over many databases, …

Cellular life depends on a complex web of functional associations between biomolecules.
Among these associations, protein–protein interactions are particularly important due to their …

The many functional partnerships and interactions that occur between proteins are at the
core of cellular processing and their systematic characterization helps to provide context in …

eggNOG is a public database of orthology relationships, gene evolutionary histories and
functional annotations. Here, we present version 5.0, featuring a major update of the underlying …

A full description of a protein's function requires knowledge of all partner proteins with which
it specifically associates. From a functional perspective, ‘association’ can mean direct …

Proteins and their functional interactions form the backbone of the cellular machinery. Their
connectivity network needs to be considered for the full understanding of biological …

Calcified dental plaque (dental calculus) preserves for millennia and entraps biomolecules
from all domains of life and viruses. We report the first, to our knowledge, high-resolution …

Much of the complexity within cells arises from functional and regulatory interactions among
proteins. The core of these interactions is increasingly known, but novel interactions …