User profiles for Christiana Ruhrberg
Christiana RuhrbergProfessor of Neuronal and Vascular Biology, University College London Verified email at ucl.ac.uk Cited by 17692 |
VEGF in the nervous system
JM Rosenstein, JM Krum, C Ruhrberg - Organogenesis, 2010 - Taylor & Francis
Vascular endothelial growth factor (VEGF, VEGFA) is critical for blood vessel growth in the
developing and adult nervous system of vertebrates. Several recent studies demonstrate that …
developing and adult nervous system of vertebrates. Several recent studies demonstrate that …
Diverse roles for VEGF-A in the nervous system
F Mackenzie, C Ruhrberg - Development, 2012 - journals.biologists.com
Vascular endothelial growth factor A (VEGF-A) is best known for its essential roles in blood
vessel growth. However, evidence has emerged that VEGF-A also promotes a wide range of …
vessel growth. However, evidence has emerged that VEGF-A also promotes a wide range of …
Growing and shaping the vascular tree: multiple roles for VEGF
C Ruhrberg - Bioessays, 2003 - Wiley Online Library
Vascular Endothelial Growth Factor (VEGF) is the most potent and ubiquitous vascular growth
factor known to date. Yet, prior to its description as a secreted mitogen for endothelial cells…
factor known to date. Yet, prior to its description as a secreted mitogen for endothelial cells…
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
…, M Golding, M Fruttiger, C Ruhrberg… - The Journal of cell …, 2003 - rupress.org
Vascular endothelial growth factor (VEGF-A) is a major regulator of blood vessel formation
and function. It controls several processes in endothelial cells, such as proliferation, survival, …
and function. It controls several processes in endothelial cells, such as proliferation, survival, …
Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction
…, F Peri, SW Wilson, C Ruhrberg - Blood, The Journal …, 2010 - ashpublications.org
Blood vessel networks expand in a 2-step process that begins with vessel sprouting and is
followed by vessel anastomosis. Vessel sprouting is induced by chemotactic gradients of the …
followed by vessel anastomosis. Vessel sprouting is induced by chemotactic gradients of the …
Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis
C Ruhrberg, H Gerhardt, M Golding… - Genes & …, 2002 - genesdev.cshlp.org
Branching morphogenesis in the mammalian lung andDrosophila trachea relies on the precise
localization of secreted modulators of epithelial growth to select branch sites and direct …
localization of secreted modulators of epithelial growth to select branch sites and direct …
Distinct macrophage phenotypes contribute to kidney injury and repair
…, S Nishio, HK Lee, BS Choi, C Ruhrberg… - Journal of the …, 2011 - journals.lww.com
The ischemically injured kidney undergoes tubular cell necrosis and apoptosis,
accompanied by an interstitial inflammatory cell infiltrate. In this study, we show that iNos-positive …
accompanied by an interstitial inflammatory cell infiltrate. In this study, we show that iNos-positive …
Mutations in dynein link motor neuron degeneration to defects in retrograde transport
M Hafezparast, R Klocke, C Ruhrberg, A Marquardt… - Science, 2003 - science.org
Degenerative disorders of motor neurons include a range of progressive fatal diseases such
as amyotrophic lateral sclerosis (ALS), spinal-bulbar muscular atrophy (SBMA), and spinal …
as amyotrophic lateral sclerosis (ALS), spinal-bulbar muscular atrophy (SBMA), and spinal …
[HTML][HTML] Macrophage-induced blood vessels guide Schwann cell-mediated regeneration of peripheral nerves
…, I Napoli, S Parrinello, T Enver, C Ruhrberg… - Cell, 2015 - cell.com
The peripheral nervous system has remarkable regenerative capacities in that it can repair a
fully cut nerve. This requires Schwann cells to migrate collectively to guide regrowing axons …
fully cut nerve. This requires Schwann cells to migrate collectively to guide regrowing axons …
Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration
Phosphoinositide 3-kinases (PI3Ks) signal downstream of multiple cell-surface receptor types.
Class IA PI3K isoforms 1 couple to tyrosine kinases and consist of a p110 catalytic subunit …
Class IA PI3K isoforms 1 couple to tyrosine kinases and consist of a p110 catalytic subunit …