Susceptibility of SARS-CoV-2 to UV irradiation

CS Heilingloh, UW Aufderhorst, L Schipper… - American journal of …, 2020 - Elsevier
The coronavirus SARS-CoV-2 pandemic became a global health burden. We determined
the susceptibility of SARS-CoV-2 to irradiation with ultraviolet light. The virus was highly …

[HTML][HTML] Glycyrrhizin effectively inhibits SARS-CoV-2 replication by inhibiting the viral main protease

…, M Bormann, M Alt, L Schipper, CS Heilingloh… - Viruses, 2021 - mdpi.com
The outbreak of SARS-CoV-2 developed into a global pandemic affecting millions of people
worldwide. Despite one year of intensive research, the current treatment options for SARS-…

[HTML][HTML] Turmeric root and its bioactive ingredient curcumin effectively neutralize SARS-CoV-2 in vitro

…, RJ Madel, M Otte, K Wuensch, CS Heilingloh… - Viruses, 2021 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2) is the causative
agent of the coronavirus disease 2019 (COVID-19). The availability of effective and well-…

[HTML][HTML] Antiviral active compounds derived from natural sources against herpes simplex viruses

L van de Sand, M Bormann, Y Schmitz, CS Heilingloh… - Viruses, 2021 - mdpi.com
Herpes simplex viruses (HSV) are ubiquitously distributed with a seroprevalence ranging up
to 95% in the adult population. Refractory viral infections with herpes simplex virus type 1 (…

Autophagic degradation of lamins facilitates the nuclear egress of herpes simplex virus type 1

…, B Sodeik, A Steinkasserer, CS Heilingloh - Journal of Cell …, 2019 - rupress.org
Dendritic cells (DCs) are crucial for the induction of potent antiviral immune responses. In
contrast to immature DCs (iDCs), mature DCs (mDCs) are not permissive for infection with …

A new promising candidate to overcome drug resistant herpes simplex virus infections

…, M Zaja, S Strobl, A Steinkasserer, CS Heilingloh - Antiviral Research, 2018 - Elsevier
Infections with Herpes simplex viruses (HSV) belong to the most common human diseases
worldwide, resulting in symptoms ranging from painful, but commonly self-limiting lesions of …

[HTML][HTML] PGAM5-MAVS interaction regulates TBK1/IRF3 dependent antiviral responses

Y Yu, M Zielinska, W Li, DB Bernkopf, CS Heilingloh… - Scientific Reports, 2020 - nature.com
Viral infections trigger host innate immune responses, characterized by the production of type-I
interferons (IFN) including IFNβ. IFNβ induces cellular antiviral defense mechanisms and …

[HTML][HTML] Mass spectrometric characterization of HSV-1 L-particles from human dendritic cells and BHK21 cells and analysis of their functional role

A Birzer, ME Kraner, CS Heilingloh… - Frontiers in …, 2020 - frontiersin.org
Herpes simplex virus type 1 (HSV-1) is a very common human pathogenic virus among the
world’s population. The lytic replication cycle of HSV-1 is, amongst others, characterized by a …

[HTML][HTML] Herpes simplex virus type-2 paralyzes the function of monocyte-derived dendritic cells

…, C Kuhnt, L Kamm, A Steinkasserer, CS Heilingloh - Viruses, 2020 - mdpi.com
Herpes simplex viruses not only infect a variety of different cell types, including dendritic
cells (DCs), but also modulate important cellular functions in benefit of the virus. Given the …

[HTML][HTML] Herpes simplex virus type 2 is more difficult to neutralize by antibodies than herpes simplex virus type 1

C Silke Heilingloh, C Lull, E Kleiser, M Alt, L Schipper… - Vaccines, 2020 - mdpi.com
Infections with herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are a global health
burden. Besides painful oral or genital lesions in otherwise healthy subjects, both viruses can …