Infiltration of Foxp3 + regulatory T (T reg) cells is considered to be a critical step during tumor
development and progression. T reg cells supposedly suppress locally an effective anti-…

Plasma IL-6 is elevated after myocardial infarction (MI) and is associated with increased
morbidity and mortality. Which cardiac cell type preferentially contributes to IL-6 expression and …

Background: T cells are required for proper healing after myocardial infarction. The mechanism
of their beneficial action, however, is unknown. The proinflammatory danger signal ATP, …

In the adult heart, the epicardium becomes activated after injury, contributing to cardiac
healing by secretion of paracrine factors. Here, we analyzed by single-cell RNA sequencing …

Type I IFN play a very important role in immunity against viral infections. Murine type I IFN
belongs to a multigene family including 14 IFN‐α subtypes but the biological functions of IFN‐α …

Insulin-like growth factor 1 (IGF1) is an anabolic hormone that controls the growth and
metabolism of many cell types. However, IGF1 also mediates cardio-protective effects after acute …

MircoRNAs (miRs) are small molecules that regulate gene expression at the posttranscriptional
level. They have been proposed to be involved in the regulation of several immune …

In our previous work we could identify defects in human regulatory T cells (Tregs) likely
favoring the development of graft-versus-host disease (GvHD) following allogeneic stem cell …

Background— Structural damage during heart failure development leads to increased
infiltration of leukocytes. Because purinergic signaling on immune cells may impact on the …

IL-6 family members contribute to host defense through the stimulation of acute-phase
signaling, hematopoiesis, immune reactions, and regenerative processes. To investigate …