The elucidation of breast cancer subgroups and their molecular drivers requires integrated
views of the genome and transcriptome from representative numbers of patients. We present …

Primary triple-negative breast cancers (TNBCs), a tumour type defined by lack of oestrogen
receptor, progesterone receptor and ERBB2 gene amplification, represent approximately 16…

Glioblastoma (GB) is the most common and aggressive primary brain malignancy, with poor
prognosis and a lack of effective therapeutic options. Accumulating evidence suggests that …

What happens in early, still undetectable human malignancies is unknown because direct
observations are impractical. Here we present and validate a'Big Bang'model, whereby …

Metastasis is the primary cause of cancer-related deaths, but the natural history, clonal evolution
and impact of treatment are poorly understood. We analyzed whole-exome sequencing …

Cancer genomics studies have identified thousands of putative cancer driver genes 1 .
Development of high-throughput and accurate models to define the functions of these genes is a …

Immunotherapies that block inhibitory checkpoint receptors on T cells have transformed the
clinical care of patients with cancer 1 . However, whether the T cell response to checkpoint …

INTRODUCTION Cancer is one of the leading causes of death worldwide. Although the 2%
of the human genome that encodes proteins has been extensively studied, much remains to …

MicroRNAs (miRNAs) show differential expression across breast cancer subtypes, and have
both oncogenic and tumour-suppressive roles 1 , 2 , 3 , 4 , 5 , 6 . Here we report the miRNA …

Crucial transitions in cancer—including tumor initiation, local expansion, metastasis, and
therapeutic resistance—involve complex interactions between cells within the dynamic tumor …