Despite success with BRAFV600E inhibitors, therapeutic responses in patients with metastatic
melanoma are short-lived because of the acquisition of drug resistance. We identified a …

NLRP3-inflammasome-driven inflammation is involved in the pathogenesis of a variety of
diseases. Identification of endogenous inflammasome activators is essential for the …

Pancreatic islet transplantation still represents a promising therapeutic strategy for curative
treatment of type 1 diabetes mellitus. However, a limited number of organ donors and …

Reactive oxygen species ( ROS ) are emerging as important regulators of cancer growth and
metastatic spread. However, how cells integrate redox signals to affect cancer progression …

Split-thickness skin grafts (STSG) are still the gold standard for the treatment of most skin
defects. Hence, there is an ongoing need to improve this procedure. For this purpose, we …

Angiogenesis is essential for the engraftment and growth of endometriotic lesions. In this study,
we analyzed whether this process is regulated by Notch signaling. Endometriotic lesions …

Non-union formation represents a major complication in trauma surgery. Adequate vascularization
has been recognized as vital for bone healing. However, the role of vascularization in …

With a great deal of interest we read the comment related to our manuscript entitled ‘Apolipoprotein
C3 induces inflammation and organ damage by alternative inflammasome activation’…

The unique microenvironment of the prostate plays a crucial role in the development and
progression of prostate cancer (PCa). We examined the effects of cancer-associated fibroblasts …

Endometriosis is a frequent gynecological disease, which is crucially dependent on the
process of angiogenesis. However, the underlying regulatory mechanisms of blood vessel …