User profiles for Christina Kyrousi

Christina Kyrousi

Assistant Professor - School of Medicine, National and Kapodistrian Univeristy of Athens …
Verified email at med.uoa.gr
Cited by 1053

[PDF][PDF] Evolution of cortical neurogenesis in amniotes controlled by robo signaling levels

…, A Villalba, C de Juan Romero, E Picó, C Kyrousi… - Cell, 2018 - cell.com
Cerebral cortex size differs dramatically between reptiles, birds, and mammals, owing to
developmental differences in neuron production. In mammals, signaling pathways regulating …

Altered neuronal migratory trajectories in human cerebral organoids derived from individuals with neuronal heterotopia

J Klaus, S Kanton, C Kyrousi, AC Ayo-Martin… - Nature medicine, 2019 - nature.com
Malformations of the human cortex represent a major cause of disability 1 . Mouse models
with mutations in known causal genes only partially recapitulate the phenotypes and are …

Mcidas and GemC1 are key regulators for the generation of multiciliated ependymal cells in the adult neurogenic niche

C Kyrousi, M Arbi, GA Pilz, DE Pefani… - …, 2015 - journals.biologists.com
Multiciliated cells are abundant in the epithelial surface of different tissues, including cells
lining the walls of the lateral ventricles in the brain and the airway epithelium. Their main role …

Cell-type-specific impact of glucocorticoid receptor activation on the developing brain: a cerebral organoid study

…, S Roeh, R Di Giaimo, C Kyrousi… - American Journal of …, 2022 - Am Psychiatric Assoc
Objective: A fine-tuned balance of glucocorticoid receptor (GR) activation is essential for organ
formation, with disturbances influencing many health outcomes. In utero, glucocorticoids …

GemC1 controls multiciliogenesis in the airway epithelium

M Arbi, DE Pefani, C Kyrousi, ME Lalioti… - EMBO …, 2016 - embopress.org
Multiciliated cells are terminally differentiated, post‐mitotic cells that form hundreds of motile
cilia on their apical surface. Defects in multiciliated cells lead to disease, including …

[HTML][HTML] Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity

C Kyrousi, AC O'neill, A Brazovskaja, Z He… - Nature …, 2021 - nature.com
Basal progenitors (BPs), including intermediate progenitors and basal radial glia, are
generated from apical radial glia and are enriched in gyrencephalic species like humans, …

[HTML][HTML] Metabolic regulation of the neural stem cell fate: Unraveling new connections, establishing new concepts

…, G Gakis, K Birmpas, C Kyrousi… - Frontiers in …, 2022 - frontiersin.org
The neural stem cell niche is a key regulator participating in the maintenance, regeneration,
and repair of the brain. Within the niche neural stem cells (NSC) generate new neurons …

ECE 2 regulates neurogenesis and neuronal migration during human cortical development

…, G Giorgio, AC O'Neill, R Di Giaimo, C Kyrousi… - EMBO …, 2020 - embopress.org
During embryonic development, excitatory projection neurons migrate in the cerebral cortex
giving rise to organised layers. Periventricular heterotopia ( PH ) is a group of aetiologically …

Cystatin B is essential for proliferation and interneuron migration in individuals with EPM 1 epilepsy

F Di Matteo, F Pipicelli, C Kyrousi, I Tovecci… - EMBO molecular …, 2020 - embopress.org
Progressive myoclonus epilepsy ( PME ) of Unverricht–Lundborg type ( EPM 1) is an
autosomal recessive neurodegenerative disorder with the highest incidence of PME worldwide. …

[PDF][PDF] A primate-specific isoform of PLEKHG6 regulates neurogenesis and neuronal migration

AC O'Neill, C Kyrousi, J Klaus, RJ Leventer, EP Kirk… - Cell reports, 2018 - cell.com
The mammalian neocortex has undergone remarkable changes through evolution. A
consequence of such rapid evolutionary events could be a trade-off that has rendered the brain …