Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase
N Ando, EJ Brignole, CM Zimanyi… - Proceedings of the …, 2011 - National Acad Sciences
Essential for DNA biosynthesis and repair, ribonucleotide reductases (RNRs) convert
ribonucleotides to deoxyribonucleotides via radical-based chemistry. Although long known that …
ribonucleotides to deoxyribonucleotides via radical-based chemistry. Although long known that …
[HTML][HTML] Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli
10.7554/eLife.07141.001 Ribonucleotide reductase (RNR) converts ribonucleotides to
deoxyribonucleotides, a reaction that is essential for DNA biosynthesis and repair. This enzyme is …
deoxyribonucleotides, a reaction that is essential for DNA biosynthesis and repair. This enzyme is …
Better, faster, cheaper: recent advances in cryo–electron microscopy
…, K Maruthi, H Kuang, CM Zimanyi… - Annual review of …, 2022 - annualreviews.org
Cryo–electron microscopy (cryo-EM) continues its remarkable growth as a method for
visualizing biological objects, which has been driven by advances across the entire pipeline. …
visualizing biological objects, which has been driven by advances across the entire pipeline. …
Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter
AT Bozzi, CM Zimanyi, JM Nicoludis, BK Lee… - Elife, 2019 - elifesciences.org
10.7554/eLife.41124.001 Nramp family transporters—expressed in organisms from bacteria
to humans—enable uptake of essential divalent transition metals via an alternating-access …
to humans—enable uptake of essential divalent transition metals via an alternating-access …
[PDF][PDF] Tangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductase
CM Zimanyi, N Ando, EJ Brignole, FJ Asturias… - Structure, 2012 - cell.com
Ribonucleotide reductases (RNRs) provide the precursors for DNA biosynthesis and repair
and are successful targets for anticancer drugs such as clofarabine and gemcitabine. …
and are successful targets for anticancer drugs such as clofarabine and gemcitabine. …
Unique structural features in an Nramp metal transporter impart substrate-specific proton cotransport and a kinetic bias to favor import
Natural resistance-associated macrophage protein (Nramp) transporters enable uptake of
essential transition metal micronutrients in numerous biological contexts. These proteins are …
essential transition metal micronutrients in numerous biological contexts. These proteins are …
Broadening access to cryoEM through centralized facilities
CM Zimanyi, M Kopylov, CS Potter, B Carragher… - Trends in biochemical …, 2022 - cell.com
Cryogenic electron microscopy (cryoEM) uses images of frozen hydrated biological specimens
to produce macromolecular structures, opening up previously inaccessible levels of …
to produce macromolecular structures, opening up previously inaccessible levels of …
A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases
N Bradshaw, VM Levdikov, CM Zimanyi, R Gaudet… - Elife, 2017 - elifesciences.org
10.7554/eLife.26111.001 PP2C phosphatases control biological processes including stress
responses, development, and cell division in all kingdoms of life. Diverse regulatory …
responses, development, and cell division in all kingdoms of life. Diverse regulatory …
Novel mutations highlight the key role of the ankyrin repeat domain in TRPV4-mediated neuropathy
JM Sullivan, CM Zimanyi, W Aisenberg… - Neurology …, 2015 - AAN Enterprises
Objective: To characterize 2 novel TRPV4 mutations in 2 unrelated families exhibiting the
Charcot-Marie-Tooth disease type 2C (CMT2C) phenotype. Methods: Direct CMT gene testing …
Charcot-Marie-Tooth disease type 2C (CMT2C) phenotype. Methods: Direct CMT gene testing …
The prototypic class Ia ribonucleotide reductase from Escherichia coli: still surprising after all these years
EJ Brignole, N Ando, CM Zimanyi… - Biochemical Society …, 2012 - portlandpress.com
RNRs (ribonucleotide reductases) are key players in nucleic acid metabolism, converting
ribonucleotides into deoxyribonucleotides. As such, they maintain the intracellular balance of …
ribonucleotides into deoxyribonucleotides. As such, they maintain the intracellular balance of …