User profiles for Christine A Orengo
 | Christine OrengoProfessor of Bioinformatics, University College London Verified email at biochem.ucl.ac.uk Cited by 41535 |
[PDF][PDF] CATH–a hierarchic classification of protein domain structures
Background: Protein evolution gives rise to families of structurally related proteins, within which
sequence identities can be extremely low. As a result, structure-based classifications can …
sequence identities can be extremely low. As a result, structure-based classifications can …
The InterPro protein families and domains database: 20 years on
The InterPro database ( https://www.ebi.ac.uk/interpro/ ) provides an integrative classification
of protein sequences into families, and identifies functionally important domains and …
of protein sequences into families, and identifies functionally important domains and …
InterPro in 2022
The InterPro database ( https://www.ebi.ac.uk/interpro/ ) provides an integrative classification
of protein sequences into families, and identifies functionally important domains and …
of protein sequences into families, and identifies functionally important domains and …
InterPro in 2017—beyond protein family and domain annotations
InterPro ( http://www.ebi.ac.uk/interpro/ ) is a freely available database used to classify
protein sequences into families and to predict the presence of important domains and sites. …
protein sequences into families and to predict the presence of important domains and sites. …
Protein superfamilles and domain superfolds
As the protein sequence and structure databases expand rapidly a better understanding of
the relationships between proteins is required. A classification is considered that extends the …
the relationships between proteins is required. A classification is considered that extends the …
Protein structure alignment
A new method of comparing protein structures is described, based on distance plot analysis.
It is relatively insensitive to insertions and deletions in sequence and is tolerant of the …
It is relatively insensitive to insertions and deletions in sequence and is tolerant of the …
Evolution of function in protein superfamilies, from a structural perspective
AE Todd, CA Orengo, JM Thornton - Journal of molecular biology, 2001 - Elsevier
The recent growth in protein databases has revealed the functional diversity of many protein
superfamilies. We have assessed the functional variation of homologous enzyme …
superfamilies. We have assessed the functional variation of homologous enzyme …
One fold with many functions: the evolutionary relationships between TIM barrel families based on their sequences, structures and functions
The eightfold (βα) barrel structure, first observed in triose-phosphate isomerase, occurs
ubiquitously in nature. It is nearly always an enzyme and most often involved in molecular or …
ubiquitously in nature. It is nearly always an enzyme and most often involved in molecular or …
[HTML][HTML] Microarray analysis after RNA amplification can detect pronounced differences in gene expression using limma
Background RNA amplification is necessary for profiling gene expression from small tissue
samples. Previous studies have shown that the T7 based amplification techniques are …
samples. Previous studies have shown that the T7 based amplification techniques are …
CATH: increased structural coverage of functional space
CATH ( https://www.cathdb.info ) identifies domains in protein structures from wwPDB and
classifies these into evolutionary superfamilies, thereby providing structural and functional …
classifies these into evolutionary superfamilies, thereby providing structural and functional …