User profiles for Christine B. Peterson

Christine B. Peterson

Associate Professor of Biostatistics, University of Texas MD Anderson Cancer Center
Verified email at mdanderson.org
Cited by 7310

Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response

…, MAW Khan, X Zhang, MG White, CB Peterson… - Science, 2021 - science.org
Gut bacteria modulate the response to immune checkpoint blockade (ICB) treatment in cancer,
but the effect of diet and supplements on this interaction is not well studied. We assessed …

[PDF][PDF] Tumor microbiome diversity and composition influence pancreatic cancer outcomes

…, SM Hanash, L Feng, JK Burks, KA Do, CB Peterson… - Cell, 2019 - cell.com
Most patients diagnosed with resected pancreatic adenocarcinoma (PDAC) survive less
than 5 years, but a minor subset survives longer. Here, we dissect the role of the tumor …

[HTML][HTML] PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma

XD Liu, W Kong, CB Peterson, DJ McGrail… - Nature …, 2020 - nature.com
A non-immunogenic tumor microenvironment (TME) is a significant barrier to immune checkpoint
blockade (ICB) response. The impact of Polybromo-1 (PBRM1) on TME and response …

Co-expression networks reveal the tissue-specific regulation of transcription and splicing

…, YS Park, P Parsana, AJ Payne, CB Peterson… - Genome …, 2017 - genome.cshlp.org
Gene co-expression networks capture biologically important patterns in gene expression
data, enabling functional analyses of genes, discovery of biomarkers, and interpretation of …

[HTML][HTML] Extracellular vesicle PD-L1 dynamics predict durable response to immune-checkpoint inhibitors and survival in patients with non-small cell lung cancer

…, P Mamindla, L Lara-Mejia, CB Peterson… - Journal of Experimental …, 2022 - Springer
Background Immune-checkpoint inhibitors (ICIs) changed the therapeutic landscape of patients
with lung cancer. However, only a subset of them derived clinical benefit and evidenced …

Controlling the rate of GWAS false discoveries

D Brzyski, CB Peterson, P Sobczyk, EJ Candès… - Genetics, 2017 - academic.oup.com
With the rise of both the number and the complexity of traits of interest, control of the false
discovery rate (FDR) in genetic association studies has become an increasingly appealing and …

Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration

…, J Wang, MA Wadud Khan, CB Peterson… - Journal of Experimental …, 2022 - rupress.org
Immune checkpoint blockade (ICB) has revolutionized cancer treatment, yet quality of life
and continuation of therapy can be constrained by immune-related adverse events (irAEs). …

Automatic detection of contouring errors using convolutional neural networks

…, L Zhang, J Yang, AS Garden, CB Peterson… - Medical …, 2019 - Wiley Online Library
Purpose To develop a head and neck normal structures autocontouring tool that could be
used to automatically detect the errors in autocontours from a clinically validated …

[HTML][HTML] Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer

…, JB Dennison, E Murage, CB Peterson… - Nature …, 2020 - nature.com
Plasma and tumor caveolin-1 (Cav-1) are linked with disease progression in prostate cancer.
Here we report that metabolomic profiling of longitudinal plasmas from a prospective …

Automatic segmentation using deep learning to enable online dose optimization during adaptive radiation therapy of cervical cancer

…, DJ Rhee, AM Venkatesan, CB Peterson… - International Journal of …, 2021 - Elsevier
Purpose This study investigated deep learning models for automatic segmentation to support
the development of daily online dose optimization strategies, eliminating the need for …