Immunohistochemical analysis of FOXP3 in primary breast tumors showed that a high number
of tumor-infiltrating regulatory T cells (Ti-Treg) within lymphoid infiltrates surrounding the …

T cells play a critical role in cancer control, but a range of potent immunosuppressive
mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their activity. …

Infiltration and dysfunction of immune cells have been documented in many types of cancers.
We previously reported that plasmacytoid dendritic cells (pDC) within primary breast …

In ovarian cancer, the immune system fails to eradicate established tumors partly due to the
induction of immune tolerance within tumor microenvironment. In this study, we investigated …

Human breast tumors are infiltrated by memory CD4 + T cells along with increased numbers
of regulatory T cells (Treg) and plasmacytoid dendritic cells (pDC) that facilitate immune …

Quantitative lymphocyte alterations are frequent in patients with cancer, and strongly impact
prognosis and survival. The development of cancers in immunosuppressed patients has …

Background Several mechanisms are present in the tumor microenvironment (TME) to
impair cytotoxic T cell responses potentially able to control tumor growth. Among these, the …

Purpose Few clinical prognostic factors have been identified for patients with metastatic renal
cell carcinoma (MRCC), and no biomarker is known in this disease. Several endogenous …

In breast carcinomas, patient survival seems to be negatively affected by the recruitment of
regulatory T cells (T reg ) within lymphoid aggregates by CCL22. However, the mechanisms …

The presence of regulatory T cells (Treg) has been described in a large panel of solid tumors.
However, their impact on tumor progression differs according to the tumor type analyzed. …