User profiles for Christine Toelzer

Christine Toelzer

University of Bristol
Verified email at bristol.ac.uk
Cited by 718

Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein

C Toelzer, K Gupta, SKN Yadav, U Borucu… - Science, 2020 - science.org
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), represents a global crisis. Key to SARS-CoV-2 therapeutic …

Molecular simulations suggest vitamins, retinoids and steroids as ligands of the free fatty acid pocket of the SARS‐CoV‐2 Spike protein

DK Shoemark, CK Colenso, C Toelzer… - Angewandte …, 2021 - Wiley Online Library
We investigate binding of linoleate and other potential ligands to the recently discovered fatty
acid binding site in the SARS‐CoV‐2 spike protein, using docking and molecular dynamics …

The free fatty acid–binding pocket is a conserved hallmark in pathogenic β-coronavirus spike proteins from SARS-CoV to Omicron

C Toelzer, K Gupta, SKN Yadav, L Hodgson… - Science …, 2022 - science.org
As coronavirus disease 2019 (COVID-19) persists, severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) emerge, accumulating spike (S) …

[HTML][HTML] Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2

K Gupta, C Toelzer, MK Williamson… - Nature …, 2022 - nature.com
As the global burden of SARS-CoV-2 infections escalates, so does the evolution of viral
variants with increased transmissibility and pathology. In addition to this entrenched diversity, …

Highly efficient CRISPR-mediated large DNA docking and multiplexed prime editing using a single baculovirus

F Aulicino, M Pelosse, C Toelzer, J Capin… - Nucleic Acids …, 2022 - academic.oup.com
CRISPR-based precise gene-editing requires simultaneous delivery of multiple components
into living cells, rapidly exceeding the cargo capacity of traditional viral vector systems. This …

[HTML][HTML] Cryo-EM reveals binding of linoleic acid to SARS-CoV-2 spike glycoprotein, suggesting an antiviral treatment strategy

C Toelzer, K Gupta, I Berger… - … Section D: Structural …, 2023 - scripts.iucr.org
The COVID-19 pandemic and concomitant lockdowns presented a global health challenge
and triggered unprecedented research efforts to elucidate the molecular mechanisms and …

Structures of nonsense-mediated mRNA decay factors UPF3B and UPF3A in complex with UPF2 reveal molecular basis for competitive binding and for …

…, KT Powers, JYA Szeto, C Toelzer… - Nucleic acids …, 2022 - academic.oup.com
UPF3 is a key nonsense-mediated mRNA decay (NMD) factor required for mRNA surveillance
and eukaryotic gene expression regulation. UPF3 exists as two paralogs (A and B) which …

Arabidopsis immunity regulator EDS1 in a PAD4/SAG101-unbound form is a monomer with an inherently inactive conformation

M Voss, C Toelzer, DD Bhandari, JE Parker… - Journal of structural …, 2019 - Elsevier
In plant innate immunity, enhanced disease susceptibility 1 (EDS1) integrates all pathogen-induced
signals transmitted by TIR-type NLR receptors. Driven by an N-terminal α/β-…

The MultiBac BEVS: Basics, applications, performance and recent developments

B Gorda, C Toelzer, F Aulicino, I Berger - Methods in Enzymology, 2021 - Elsevier
The baculovirus expression vector system (BEVS) delivers high yield heterologous protein
expression and is widely used in academic and industrial R&D. The proteins produced …

[PDF][PDF] Engineering the ADDobody protein scaffold for generation of high-avidity ADDomer super-binders

D Buzas, H Sun, C Toelzer, SKN Yadav, U Borucu… - Structure, 2024 - cell.com
Adenovirus-derived nanoparticles (ADDomer) comprise 60 copies of adenovirus penton
base protein (PBP). ADDomer is thermostable, rendering the storage, transport, and …