Neutrophils are crucial mediators of host defense that are recruited to the central nervous
system (CNS) in large numbers during acute bacterial meningitis caused by Streptococcus …

Severe coronavirus disease 2019 (COVID-19) can result in pneumonia and acute respiratory
failure. Accumulation of mucus in the airways is a hallmark of the disease and can result in …

Sepsis is the major cause of mortality across intensive care units globally, yet details of
accompanying pathological molecular events remain unclear. This knowledge gap has resulted …

Toll-like receptor (TLR) signaling is important in the initiation of immune responses and
subsequent instigation of adaptive immunity. TLR2 recognizes bacterial lipoproteins and plays a …

Background Cystic fibrosis (CF), involves excessive airway accumulation of neutrophils, often
in parallel with severe infection caused by Pseudomonas aeruginosa. Free histones are …

Infectious diseases are characterized by a complex interplay between host and pathogen,
but how these interactions impact the host proteome is unclear. Here we applied a combined …

IdeS is a streptococcal protease that cleaves IgG antibodies into F(ab’) 2 and Fc fragments
with a unique degree of specificity, thereby providing a novel treatment opportunity of IgG-…

Background Prokaryotes dominate the biosphere and regulate biogeochemical processes
essential to all life. Yet, our knowledge about their biology is for the most part limited to the …

The anaerobic bacterium Finegoldia magna is part of the human commensal microbiota, but
is also an important opportunistic pathogen. This bacterium expresses a subtilisin-like …

Streptococcus pyogenes is a major human bacterial pathogen responsible for severe and
invasive disease associated with high mortality rates. The bacterium interacts with several …