Receptor-interacting protein kinase 3 (RIPK3)-mediated necroptosis is thought to be the
pathophysiologically predominant pathway that leads to regulated necrosis of parenchymal …

Background The aim of this study was to establish and validate a practical method to disperse
nanoparticles in physiological solutions for biological in vitro and in vivo studies. Results …

In AKI, dying renal cells release intracellular molecules that stimulate immune cells to secrete
proinflammatory cytokines, which trigger leukocyte recruitment and renal inflammation. …

Under steady-state conditions, aged neutrophils are removed from the circulation in bone
marrow, liver, and spleen, thereby maintaining myeloid cell homeostasis. The fate of these …

Effective immune responses require the directed migration of leukocytes from the vasculature
to the site of injury or infection. How immune cells “find” their site of extravasation remains …

Junctional adhesion molecule-A (JAM-A) is a transmembrane protein expressed at tight
junctions of endothelial and epithelial cells and on the surface of platelets and leukocytes. The …

Carcinoma cells undergo epithelial-mesenchymal transition (EMT); however, contributions of
EMT heterogeneity to disease progression remain a matter of debate. Here, we addressed …

Background Head and neck squamous cell carcinoma (HNSCC) remain a substantial burden
to global health. Cell-free circulating tumour DNA (ctDNA) is an emerging biomarker but …

OBJECTIVES: Although ambient nanoparticles have been shown to exert prothrombotic
effects, manufactured nanoparticles are in this aspect less well investigated. Thus, the aim of …

Background Epidermal growth factor receptor (EGFR) is both a driver oncogene and a
therapeutic target in advanced head and neck squamous cell carcinoma (HNSCC). However, …