An efficient Rh(III)-catalyzed oxidative olefination by directed C−H bond activation of N-methoxybenzamides
is reported. In this mild, practical, selective, and high-yielding process, the N…

The SARS‐CoV‐2 coronavirus encodes an essential papain‐like protease domain as part
of its non‐structural protein (nsp)‐3, namely SARS2 PLpro, that cleaves the viral polyprotein, …

Taking advantage of Rh(III)-catalyzed C–H activation reactions, we have developed a mild,
short, and efficient method for the synthesis of bench-stable 3-isoquinolone MIDA boronates. …

MicroRNAs are a recently discovered new class of important endogenous regulators of gene
function. Aberrant regulation of microRNAs has been linked to various human diseases, …

An efficient Rh(III)-catalyzed direct C–H amination of N-pivaloyloxy benzamides with N-chloroamines
proceeding at room temperature was achieved. The versatile directing group …

Seven! The title reaction can be described as an intermolecular annulation involving tandem
CH activation, cyclization to give the seven‐membered ring, and condensation steps. …

The Rh(III)-catalyzed amidation of C(sp 2 )–H bonds by the use of electron-deficient
aroyloxycarbamates as efficient electrophilic amidation partners is reported. The reaction proceeded …

The Kelch-like ECH-associated protein 1 (KEAP1) - nuclear factor erythroid 2-related factor 2
(NRF2) signaling pathway senses reactive oxygen species and regulates cellular oxidative …

Modulation of protein abundance using tag-Targeted Protein Degrader (tTPD) systems
targeting FKBP12 F36V (dTAGs) or HaloTag7 (HaloPROTACs) are powerful approaches for …

Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated
approach to cancer therapy. In contrast, blocking apoptosis to prevent the death of healthy …