User profiles for Christoph Thiemermann

Christoph Thiemermann

Centre Lead for Translational Medicine & Therapeutics, Queen Mary University of London
Verified email at qmul.ac.uk
Cited by 36817

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

…, P Akarasereenont, C Thiemermann… - Proceedings of the …, 1993 - National Acad Sciences
Constitutive cyclooxygenase (COX-1; prostaglandin-endoperoxide synthase, EC 1.14.99.1)
is present in cells under physiological conditions, whereas COX-2 is induced by some …

Erythropoietin protects the kidney against the injury and dysfunction caused by ischemia-reperfusion

…, S Harwood, M Raftery, C Thiemermann… - Journal of the …, 2004 - journals.lww.com
ABSTRACT. Erythropoietin (EPO) is upregulated by hypoxia and causes proliferation and
differentiation of erythroid progenitors in the bone marrow through inhibition of apoptosis. EPO …

[HTML][HTML] Role of metabolic endotoxemia in systemic inflammation and potential interventions

S Mohammad, C Thiemermann - Frontiers in immunology, 2021 - frontiersin.org
Diet-induced metabolic endotoxemia is an important factor in the development of many chronic
diseases in animals and man. The gut epithelium is an efficient barrier that prevents the …

Ligands of the peroxisome proliferator‐activated receptors (PPAR‐γ and PPAR‐α) reduce myocardial infarct size

…, B PISANO, PK Chatterjee, C Thiemermann - The FASEB …, 2002 - Wiley Online Library
This study was designed to investigate the effects of various chemically distinct activators of
PPAR‐γ and PPAR‐α in a rat model of acute myocardial infarction. Using Northern blot …

Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo

C Thiemermann, J Vane - European journal of pharmacology, 1990 - Elsevier
E. coli lipopolysaccharide (LPS; 15 mg kg −1 iv) produced a long-lasting reduction in mean
arterial blood pressure (MAP) in the anaesthetized rat. Inhibition of nitric oxide endothelium-…

[HTML][HTML] Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat

…, KN Stewart, H Mota-Filipe, C Thiemermann - Kidney international, 2000 - Elsevier
Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal
dysfunction and injury in the rat. Background The generation of reactive oxygen species (…

Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide.

C Thiemermann, C Szabo… - Proceedings of the …, 1993 - National Acad Sciences
This study investigates the role of nitric oxide (NO) and the induction of a calcium-independent
NO synthase (NOS) in development of vascular hyporeactivity to norepinephrine (NE) …

The cell wall components peptidoglycan and lipoteichoic acid from Staphylococcus aureus act in synergy to cause shock and multiple organ failure.

…, M Kengatharan, C Thiemermann… - Proceedings of the …, 1995 - National Acad Sciences
Although the incidence of Gram-positive sepsis has risen strongly, it is unclear how Gram-positive
organisms (without endotoxin) initiate septic shock. We investigated whether two cell …

Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin

…, B Sepodes, C Thiemermann… - Proceedings of the …, 2008 - National Acad Sciences
Erythropoietin (EPO), a member of the type 1 cytokine superfamily, plays a critical hormonal
role regulating erythrocyte production as well as a paracrine/autocrine role in which locally …

Nitric oxide and septic shock

C Thiemermann - General Pharmacology: The Vascular System, 1997 - Elsevier
… Thus, further studies aimed at evaluating the effects of iNOSselective NOS inhibitors on
cardiac function in septic shock are warranted (Thiemermann, 1994, 1995). Circulatory shock …