User profiles for Christophe Arnoult
 | Christophe ArnoultDirecteur de recherche CNRS Verified email at univ-grenoble-alpes.fr Cited by 7286 |
[PDF][PDF] Mutations in DNAH1, which encodes an inner arm heavy chain dynein, lead to male infertility from multiple morphological abnormalities of the sperm flagella
Ten to fifteen percent of couples are confronted with infertility and a male factor is involved
in approximately half the cases. A genetic etiology is likely in most cases yet only few genes …
in approximately half the cases. A genetic etiology is likely in most cases yet only few genes …
Teratozoospermia: spotlight on the main genetic actors in the human
…, J Escoffier, G Martinez, C Arnoult… - Human reproduction …, 2015 - academic.oup.com
BACKGROUND Male infertility affects >20 million men worldwide and represents a major
health concern. Although multifactorial, male infertility has a strong genetic basis which has so …
health concern. Although multifactorial, male infertility has a strong genetic basis which has so …
Ca2+ Entry through Store-operated Channels in Mouse Sperm Is Initiated by Egg ZP3 and Drives the Acrosome Reaction
CMB O'Toole, C Arnoult, A Darszon… - Molecular biology of …, 2000 - Am Soc Cell Biol
Fertilization occurs after the completion of the sperm acrosome reaction, a secretory event
that is triggered during gamete adhesion. ZP3, an egg zona pellucida glycoprotein, produces …
that is triggered during gamete adhesion. ZP3, an egg zona pellucida glycoprotein, produces …
The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation
…, L Willems, M Lambert, C Arnoult… - Blood, The Journal …, 2010 - ashpublications.org
Finding an effective treatment for acute myeloid leukemia (AML) remains a challenge, and all
cellular processes that are deregulated in AML cells should be considered in the design of …
cellular processes that are deregulated in AML cells should be considered in the design of …
Control of the low voltage-activated calcium channel of mouse sperm by egg ZP3 and by membrane hyperpolarization during capacitation
C Arnoult, IG Kazam, PE Visconti… - Proceedings of the …, 1999 - National Acad Sciences
Sperm adhesion to egg zonae pellucidae initiates sperm acrosome reactions, an exocytotic
event that is an early step during fertilization. Previously, it was suggested that zona pellucida…
event that is an early step during fertilization. Previously, it was suggested that zona pellucida…
[PDF][PDF] A recurrent deletion of DPY19L2 causes infertility in man by blocking sperm head elongation and acrosome formation
An increasing number of couples require medical assistance to achieve a pregnancy, and
more than 2% of the births in Western countries now result from assisted reproductive …
more than 2% of the births in Western countries now result from assisted reproductive …
Absence of Dpy19l2, a new inner nuclear membrane protein, causes globozoospermia in mice by preventing the anchoring of the acrosome to the nucleus
Sperm-head elongation and acrosome formation, which take place during the last stages of
spermatogenesis, are essential to produce competent spermatozoa that are able to cross the …
spermatogenesis, are essential to produce competent spermatozoa that are able to cross the …
Activation of mouse sperm T-type Ca2+ channels by adhesion to the egg zona pellucida
C Arnoult, RA Cardullo, JR Lemos… - Proceedings of the …, 1996 - National Acad Sciences
The sperm acrosome reaction is a Ca 2+ -dependent exocytotic event that is triggered by
adhesion to the mammalian egg’s zona pellucida. Previous studies using ion-selective …
adhesion to the mammalian egg’s zona pellucida. Previous studies using ion-selective …
[HTML][HTML] Mutations in CFAP43 and CFAP44 cause male infertility and flagellum defects in Trypanosoma and human
Spermatogenesis defects concern millions of men worldwide, yet the vast majority remains
undiagnosed. Here we report men with primary infertility due to multiple morphological …
undiagnosed. Here we report men with primary infertility due to multiple morphological …
A perspective on the control of mammalian fertilization by egg-activated ion channels in sperm: a tale of two channels
HM Florman, C Arnoult, IG Kazam, C Li… - Biology of …, 1998 - academic.oup.com
Mammalian sperm contain a single large secretory vesicle, or acrosome. Exocytosis of this
vesicle (the acrosome reaction) occurs as an early step in the gamete interaction process and …
vesicle (the acrosome reaction) occurs as an early step in the gamete interaction process and …