Oncogene-induced cellular senescence (OIS) is emerging as a potent cancer-protective
response to oncogenic events, serving to eliminate early neoplastic cells from the proliferative …

Aluminum-based adjuvants (aluminum salts or alum) are widely used in human vaccination,
although their mechanisms of action are poorly understood. Here we report that, in mice, …

Increases in eosinophil numbers are associated with infection and allergic diseases, including
asthma, but there is also evidence that eosinophils contribute to homeostatic immune …

Living in a microbe-rich environment reduces the risk of developing asthma. Exposure of
humans or mice to unmethylated CpG DNA (CpG) from bacteria reproduces these protective …

The demand is currently high for new vaccination strategies, particularly to help combat
problematic intracellular pathogens, such as HIV and malarial parasites. In the past decade, the …

The respiratory tract is continuously exposed to both innocuous airborne antigens and
immunostimulatory molecules of microbial origin, such as LPS. At low concentrations, airborne …

Interferons (IFNs) are a group of cytokines with a well-established antiviral function. They
can be induced by viral infection, are secreted and bind to specific receptors on the same or …

Metastasis confronts clinicians with two major challenges: estimating the patient's risk of
metastasis and identifying therapeutic targets. Because they are key signal integrators …

Quantitative and qualitative changes in mRNA translation occur in tumor cells and support
cancer progression and metastasis. Posttranscriptional modifications of transfer RNAs (tRNAs…

Knockout mice studies have revealed that NF-κB plays a critical role in Th2 cell differentiation
and is therefore required for induction of allergic airway inflammation. However, the …