The B‐cell activity factor (BAFF) acts as a positive regulator of B‐cell function. To gain further
insight into the understanding of B‐cell hyperactivity in autoimmune diseases, the serum …

Objective. There is evidence to support a dominant role for B cells in the pathophysiology of
primary Sjögren's syndrome

There is currently no approved treatment for primary Sjögren’s syndrome, a disease that
primarily affects adult women. The difficulty in developing effective therapies is -in part- because …

Rapid Publication Page 1 Autoantibody-induced Apoptosis of Endothelial Cells 2029 J. Clin.
Invest. © The American Society for Clinical Investigation, Inc. 0021-9738/98/05/2029/07 …

Regulatory functions for B lymphocytes have been reported in murine models of autoimmune
diseases in which B-cell deficient mice were shown to exhibit exacerbated disease. The B …

The origin of CD5 + B cells remains controversial. The differential response to ligation of CD5
resulting in apoptosis or proliferation provides insight into its roles in distinct human B cells…

Regulatory B cells (Bregs) may act earlier than regulatory T cells (Tregs) and may play as
important a role in autoimmune and allergic diseases. Obstacles to the investigation of Bregs …

The oncogenic Epstein-Barr virus (EBV) evades the immune system but has an Achilles heel:
its genome maintenance protein EBNA1, which is essential for viral genome maintenance …

Objective Clinical heterogeneity, a hallmark of systemic autoimmune diseases, impedes
early diagnosis and effective treatment, issues that may be addressed if patients could be …

Rheumatoid factors (RF), which are antibodies (Ab) with specificity directed against gamma (γ)
globulins, are the commonest auto-Ab ever described in man. Some of them are referred …