Recent advances in single-cell transcriptomics are ideally placed to unravel intratumoral
heterogeneity and selective resistance of cancer stem cell (SC) subpopulations to molecularly …

Tumours most often arise from progression of precursor clones within a single anatomical
niche. In the bone marrow, clonal progenitors can undergo malignant transformation to acute …

Sex bias in cancer is well recognized, but the underlying mechanisms are incompletely
defined. We connect X chromosome mutations in ZRSR2 to an extremely male-predominant …

Lympho-myeloid restricted early thymic progenitors (ETPs) are postulated to be the cell of
origin for ETP leukemias, a therapy-resistant leukemia associated with frequent co-occurrence …

Although previous studies suggested that the expression of FMS-like tyrosine kinase 3 (Flt3)
initiates downstream of mouse hematopoietic stem cells (HSCs), FLT3 internal tandem …

Juvenile myelomonocytic leukemia (JMML) is a poor-prognosis childhood leukemia usually
caused by RAS-pathway mutations. The cellular hierarchy in JMML is poorly characterized, …

Yolk sac (YS) hematopoiesis is critical for the survival of the embryo and a major source of
tissue-resident macrophages that persist into adulthood. Yet, the transcriptional and …

Despite the well-established cell-intrinsic role of epigenetic factors in normal and malignant
hematopoiesis, their cell-extrinsic role remains largely unexplored. Herein we investigated …

Somatic mutations in acute myeloid leukemia are acquired sequentially and hierarchically.
First, pre-leukemic mutations, such as t (8; 21) that encodes AML1-ETO, are acquired within …

Phosphoinositide 3-kinase gamma (PI3Kγ) is implicated as a target to repolarize tumor-associated
macrophages and promote anti-tumor immune responses in solid cancers. However, …