Genome-scale studies have revealed extensive, cell type-specific colocalization of transcription
factors, but the mechanisms underlying this phenomenon remain poorly understood. …

How transcription affects genome 3D organization is not well understood. We found that during
influenza A (IAV) infection, rampant transcription rapidly reorganizes host cell chromatin …

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019
has triggered an ongoing global pandemic of the severe pneumonia-like disease …

A critical component in the interpretation of systems-level studies is the inference of enriched
biological pathways and protein complexes contained within OMICs datasets. Successful …

The human body contains several hundred cell types, all of which share the same genome.
In metazoans, much of the regulatory code that drives cell type-specific gene expression is …

Recent studies suggest a hierarchical model in which lineage-determining factors act in a
collaborative manner to select and prime cell-specific enhancers, thereby enabling signal-…

Rev-Erb-α and Rev-Erb-β are nuclear receptors that regulate the expression of genes involved
in the control of circadian rhythm 1 , 2 , metabolism 3 , 4 and inflammatory responses 5 . …

It is now established that the transcription factors E2A, EBF1 and Foxo1 have critical roles in
B cell development. Here we show that E2A and EBF1 bound regulatory elements present …

The role of adaptive immunity in early cancer development is controversial. Here we show
that chronic inflammation and fibrosis in humans and mice with non-alcoholic fatty liver …

Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an extended
polyglutamine repeat in the N terminus of the Huntingtin protein (HTT). Reactive microglia and …