Gene expression involves transcription, translation and the turnover of mRNAs and proteins.
The degree to which protein abundances scale with mRNA levels and the implications in …

Detailed knowledge of the molecular biology of severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) infection is crucial for understanding of viral replication, host responses, …

A remarkable observation emerging from recent cancer genome analyses is the identification
of chromothripsis as a one‐off genomic catastrophe, resulting in massive somatic DNA …

The coronavirus disease 2019 (COVID-19) pandemic, caused by the novel severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing global health threat with …

Chromosome instability (CIN) is associated with poor survival and therapeutic outcome in a
number of malignancies. Despite this correlation, CIN can also lead to growth disadvantages…

Chromosome loss that results in monosomy is detrimental to viability, yet it is frequently
observed in cancers. How cancers survive with monosomy is unknown. Using p53-deficient …

Chromosome instability ( CIN ) has been associated with therapeutic resistance in many
cancers. However, whether tumours become genomically unstable as an evolutionary …

Patterns of gene expression in tumors can arise as a consequence of or result in genomic
instability, characterized by the accumulation of somatic copy number alterations (SCNAs) and …

… Carlotta Welters, María Fernanda Lammoglia Cobo, Christian Alexander Stein, Meng-Tung
Hsu, Amin Ben Hamza, Livius Penter, Xiaojing Chen, Christopher Buccitelli, Oliver Popp, …

CRISPR-mediated genome engineering provides a powerful tool to study the function of
genes and proteins. In the past decades, the advances in genome and transcriptome …