Charting differences between tumors and normal tissue is a mainstay of cancer research.
However, clonal tumor expansion from complex normal tissue architectures potentially …

Several mechanisms of action have been proposed for DNA methyltransferase and histone
deacetylase inhibitors (DNMTi and HDACi), primarily based on candidate-gene approaches. …

There is a concern that increased paternal age may be associated with altered fertility and an
increased incidence of birth defects in man. In previous studies of aged male rats, we have …

Although clonal selection by genetic driver aberrations in cancer is well documented, the
ability of epigenetic alterations to promote tumor evolution is undefined. We used 450k arrays …

As new generations of targeted therapies emerge and tumor genome sequencing discovers
increasingly comprehensive mutation repertoires, the functional relationships of mutations …

Prostate cancer is driven by a combination of genetic and/or epigenetic alterations. Epigenetic
alterations are frequently observed in all human cancers, yet how aberrant epigenetic …

Purpose Increased ZAP-70 expression predicts poor prognosis in chronic lymphocytic
leukemia (CLL). Current methods for accurately measuring ZAP-70 expression are problematic, …

Novel agents such as the Bcl-2 inhibitor venetoclax (ABT-199) are changing treatment paradigms
for chronic lymphocytic leukemia (CLL) but important problems remain. Although some …

Recently, the European LeukemiaNet (ELN) revised its genetic-risk classification of acute
myeloid leukemia (AML). We categorized 1637 adults with AML treated with cytarabine/…

Classical hairy cell leukemia (cHCL) is characterized by a near 100% frequency of the
BRAFV600E mutation, whereas ∼30% of variant HCLs (vHCLs) have MAP2K1 mutations. …