A recent focus meeting on Controlling Acute Inflammation was held in London, April 27-28,
2006, organized by DW Gilroy and SD Brain for the British Pharmacology Society. We …

The spondyloarthropathies are a group of rheumatic diseases that are associated with
inflammation at anatomically distal sites, particularly the tendon-bone attachments (entheses) and …

Inflammatory responses, like all biological cascades, are shaped by a delicate balance
between positive and negative feedback loops. It is now clear that in addition to positive and …

CD4 + T cells are central mediators of autoimmune pathology; however, defining their key
effector functions in specific autoimmune diseases remains challenging. Pathogenic CD4 + T …

Fibroblasts are important sentinel cells in the immune system and, here, it is proposed that
these cells play a critical role in the switch from acute inflammation to adaptive immunity and …

The identification of lymphocyte subsets with non-overlapping effector functions has been
pivotal to the development of targeted therapies in immune-mediated inflammatory diseases (…

Immune-regulatory mechanisms of drug-free remission in rheumatoid arthritis (RA) are
unknown. We hypothesized that synovial tissue macrophages (STM), which persist in remission, …

Synthetic peptides containing the arginine–glycine–aspartate (RGD) motif have been used
extensively as inhibitors of integrin–ligand interactions in studies of cell adhesion, migration, …

Pathological processes involved in the initiation of rheumatoid synovitis remain unclear. We
undertook the present study to identify immune and stromal processes that are present soon …

Periodontitis is a chronic inflammatory disease that is characterized by loss of the periodontal
ligament and alveolar bone, and is a major cause of tooth loss. Results from clinical and …